The efficacy of employing intra-articular 3-Dimensional (D) mesenchymal stem cell (MSC) therapy to heal hip labral tear as an alternative to orthopaedic surgery is investigated in this study.
Repetitive trauma, especially in sports, is a common cause of chronic labral tear. Capsular hip hypermobility, femoroacetabular impingement, acetabular dysplasia, and hip osteoarthritis are some of the other causes.
Experts have concluded that no labrum area has the ability to heal due to the minor penetration of vessels into the labrum and the lack of blood flow, and no clinical investigations have shown that labral tears heal. A labral tear has been linked to chondral damage and the development of early osteoarthritis. In symptomatic situations, surgery is the sole option for debriding and correcting labral tears and accompanying structural problems. MSCs express a chondrocyte differential viewpoint and create extracellular matrix (ECM) molecules and regulatory signals, which may help to repair the injured hip joint, according to the rationale above.
We present the case of a 32-year-old male lawyer with an athletic history who developed right acetabular dysplasia, which resulted in significant labral rips and para-labral cysts. We used FDA-approved bovine collagen type 1 crossed-linked with hyaluronic acid to make a durable hydrogel to treat him with experimental 3D expanded stem cell cultivation. As a hip-preserving technique, the surgeon performed a corrected extra-articular osteotomy on his right hip one month following the stem cell therapy. He underwent physical rehabilitation following his therapy. He described a fantastic clinical and radiological outcome. An MRI five and a half months after therapy revealed that severe labral rips had been repaired and that para-labral cysts had completely resolved. He was able to resume regular exercycle training and walking with ease. This case represents world-class results with positive clinical and radiological outcomes after using experimental 3D stem cell culture with the added benefit of an extracellular matrix, which has enormous potential for non-surgical tissue repair and regeneration of joint structures. Randomized controlled trials are highly recommended for demonstrating consistency of outcomes.Author(S) Details
Hassan Mubark
Department of Rheumatology, Auckland Regenerative Clinic, Ormiston Specialist Centre, New Zealand.
View Book:- https://stm.bookpi.org/IDMMR-V4/article/view/5539
No comments:
Post a Comment