The ascorbyl radical is produced by the one-electron oxidation of ascorbate, and it has been proposed as a marker of oxidative stress in vitro and in vivo in a variety of systems. We were able to estimate the steady state concentration of using a simple kinetic analysis. These findings were compared to experimental values obtained in the rat brain under physiological conditions and in response to stress caused by subchronic Fe overload. The major goal of this chapter is to expand on the information offered in a previously published work by applying a basic kinetic model created to estimate steady state concentration to other Fe-dependent oxidative situations in the rat brain to other Fe-dependent oxidative conditions. Acute Fe-overload appears to alter steady-state concentration via a more complex route network than sub-chronic Fe-overload, according to this data. The mechanisms that govern living organisms' responses to toxicologically relevant challenges will be better understood thanks to the mechanistic investigation given here.
Author(S) Details
Natacha E. Piloni
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Fisicoquímica, Buenos Aires, Argentina and CONICET-Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Buenos Aires, Argentina.
Susana Puntarulo
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Fisicoquímica, Buenos Aires, Argentina and CONICET-Universidad de Buenos Aires, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Buenos Aires, Argentina.
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