The efficacy of local implantation of biological treatment to restore injured calf muscles and tendons is investigated in this study. The Achilles tendon (AT) is one of the most commonly torn tendons in the lower leg. During strong physical activity that include quick swivelling on a foot or a fast burst of speed, sudden forces apply to the Achilles tendon, causing it to rupture. Pain, ankle stiffness, and diminished strength are common symptoms of chronic AT rupture, which develops 4-6 weeks after the initial injury. When there is a substantial gap between the tendon ends, reconstruction is required, most typically via flexor hallucis longus tendon (FHLT) transfer for any abnormalities above 2cm. A 44-year-old female patient experienced a left AT rupture during a netball game in this case report. She received conservative treatment at first, but it ruptured again spontaneously, needing reconstruction surgery with FHLT transfer. At the transplanted musculo-Achilles junction, she suffered calf muscle weakness and atrophy. Her symptoms included calf muscle atrophy and weakness, as well as the inability to complete a single heel rise. The score on the Foot and Ankle Disability Index (FADI) was 74. Her orthopaedic surgeon refused to perform any additional surgery because it would be of no advantage to her. She has chosen an autologous adipose-derived expanded mesenchymal stem cell treatment (MSCs) and platelet-rich plasma (PRP) experiment (PRP). She had a favourable outcome six months after the treatment, as demonstrated by increased everyday activities, heel-raising, and running slowly for the first time in several years after reconstruction surgery. Her FADI score improved to 91.3, and a six-month MRI revealed an enhanced signal at the musculo-Achilles junction, indicating that the injury was healing. This example shows that a single MSC and PRP treatment resulted in a favourable outcome, demonstrating that MSC therapy can be used to heal lost calf muscle and tendon from previous scarring.
Author(S) Details
Hassan Mubark
Department of Rheumatology, Auckland Regenerative Clinic, Ormiston Specialist Centre, New Zealand.
View Book:- https://stm.bookpi.org/IDMMR-V3/article/view/5476
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