The goal of this study is to see if a cellular biological treatment can take the role of surgery in terms of regulating symptoms, delaying or preventing the course of osteoarthritis (OA), and fixing faults. In the various stages of knee OA, bone marrow oedema and subchondral bone cysts are common observations. Once the degenerative process begins, it advances to severe OA, followed by a high likelihood of metal knee replacement. There is currently no effective therapy to change the course of OA. A fifty-four-year-old salesperson who enjoys active athletics is profiled in this article. He had OA in his right knee that was causing him pain. Patellofemoral subchondral bone marrow oedema and several subchondral cysts were discovered on an MRI scan of his knee. Meniscus injury in the medial compartment, as well as medial and patellofemoral cartilage loss. He was suffering from a big baker cyst and synovitis. An ultrasound-guided steroid injection had no effect on him. Despite this, a single dosage of autologous fat-derived expanded mesenchymal stem cells (MSCs) mixed with platelet-rich plasma had a remarkable effect on him (PRP). Three months after starting therapy, he was symptom-free, and this continued. A nine-month follow-up MRI revealed a little baker cyst and a considerable reduction in synovitis due to MSCs' anti-inflammatory action. A follow-up MRI 33 months after treatment indicated complete clearance of bone marrow oedema and several subchondral patellofemoral bone cysts. This case had promising results, which may transform how we practise medicine in the treatment of OA as a step before surgery.
Author(S) Details
Hassan Mubark
Department of Rheumatology, Auckland Regenerative Clinic, Ormiston Specialist Centre, New Zealand.
View Book:- https://stm.bookpi.org/IDMMR-V3/article/view/5475
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