Study on Heart rate Variability and Heart Rate under General Anesthesia in Rats of Both Sexes | Chapter 02 | Issues and Developments in Medicine and Medical Research Vol. 5

 The effects of general anaesthesia on autonomic function and baroreflex regulation are well documented. Intravenous anaesthetics can affect the activity of sympathetic or parasympathetic divisions of the autonomic nervous system (ANS) by having various qualitative and quantitative effects on the peripheral autonomic nervous system (ANS). There is currently a scarcity of information on sex differences in ANS activity or sex differences in ANS activities under anaesthesia.

The primary goal of this study was to see how spectral powers of heart rate variability (HRV) affected changes in heart rate (HR), total spectral power of HRV, and the low-frequency (LF)/high-frequency (HF) ratio in healthy, sexually mature rats of both sexes spontaneously breathing during the light (inactive) and dark (active) periods of their regimen day.

Experiments were carried out on male and female Wistar rats anaesthetized with zoletil (30 mg/kg [intraperitoneal]) after a four-week adaptation to a light-dark (LD) cycle (12h:12h). According to sex and light period, the mice were placed into four experimental groups (n=20 each). HR, HRV spectral powers (very low frequency, LF, and HF), and the LF/HF ratio were measured 20 minutes after anaesthesia was administered.

Conclusions and Results: In both sexes and during both light times of the regimen day, Zoletil had a tachycardic impact. The autonomic nervous system was engaged in HR changes in both light periods in females, while HR was not dependent on autonomic nervous system activity in males; as a result, the authors assume that it was primarily driven by other factors. HRV was determined in females by sympathetic and baroreflex activity during both light times, whereas HRV was determined in males by parasympathetic activity during both light phases. The effect of LF on the LF/HF ratio was substantial in females but not in males, whereas the effect of HF on the LF/HF ratio was minimal in both sexes and light periods.

Author(S) Details

P. Svorc
Department of Physiology, Medical Faculty Safarik’s University, Kosice, Slovak Republic and Department of Physiology and Pathophysiology, Medical Faculty Ostrava University, Ostrava, Czech Republic.

D. Petrasova
Laboratory of Research Bio-models, Medical Faculty Safarik’s University, Kosice, Slovak Republic.

P. Svorc Jr
Department of Physiology and Pathophysiology, Medical Faculty Ostrava University, Ostrava, Czech Republic.

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