Brain stroke is one of the primary causes of death in the absence of proper treatment. Fragaria nubicola has potential antioxidant action and may be cytoprotective against ischemia-reperfusion brain injury due to the presence of phenolic chemicals. ellagic acid and phenolic compounds are abundant in Fragaria nubicola. We used neurobehavioral tests such as the neurodeficit score, beam walk test, rota rod test, hanging wire test, and elevated plus maze to investigate the effect of fresh Fragaria nubicola fruit juice (10 ml/kg, p.o.) and vitamin E as a reference standard drug on 30 minutes of induced ischemia followed by reperfusion. The biochemical parameters of nitric oxide, malondialdehyde, superoxide dismutase, and catalase were evaluated in the brains of control and treated rats. Fragaria nubicola fresh fruit juice increased neurobehavioral measures such as motor performance [neurological status, significant increase in grasping ability (P0.05), forelimb strength (P0.05), improvement in balance and co-ordination (P0.05)]. In rat brains, biochemical measurements demonstrated a significant increase in the activity of enzyme antioxidants such as catalase (P0.01), superoxide dismutase (P0.01), total nitrite (P0.01), and lipid peroxidation (P0.01). The juice of F. nubicola fruits (strawberry) has the most strong cytoprotective action, according to the data.
Author(S) Details
Purushottam B. Rakhunde
Department of Pharmacology, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad (M.S.), India.
Syed Ayaz Ali
Department of Pharmacology, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad (M.S.), India.
Subur W. Khan
Department of Pharmacognosy, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad (M.S.), India.
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