Clinico Haematological Profile in Paediatric Patients with Bicytopenia and Pancytopenia in a Tertiary Care Referral Centre of North India: A Prospective Observational Study | Chapter 03 | Current Aspects in Pharmaceutical Research and Development Vol. 7

 Background: When compared to paediatric patients, bicytopenia and pancytopenia are very typical presentations in adults. Pancytopenia/Bicytopenia manifests itself in a variety of ways in children, ranging from temporary bone marrow suppression to marrow invasion by life-threatening cancers. The findings in the bone marrow might range from normocellular with non-specific alterations to hypercellular with malignant cells overshadowing it, depending on the underlying reasons.

The goal of this study is to look at the clinical and haematological profiles of children with Cytopenias. The goal of this study is to determine the severity of haematological findings in patients with Pancytopenia and Bicytopenia based on the causal variables.

Methods: A prospective observational study was undertaken at Dr. RPGMC Tanda Himachal Pradesh's Department of Paediatrics (INDIA). All patients were included in the trial, with the exception of those who met the exclusion criteria. It was carried out after receiving verbal and written informed consent. From March 2013 to March pancytopenia, a total of 50 children with bicytopenia and pancytopenia were enrolled. Infection caused bicytopenia in 14 (20%) and pancytopenia in 8 (16%) of the cases. Scrub typhus was the most frequent infection in 1890. (32 percent ). Leukemia was found in 11 (22% of the cases).

Conclusions: The most common age group affected was 11-15 years old, with female dominance at a ratio of 0.78:1. Fever was the most prevalent symptom in 37 percent of cases, followed by widespread weakness in 29 percent of cases. Pallor was the most prevalent symptom in 43 (86%) of the patients, followed by hepatomegaly in 32 (64%), lymphadenopathy in 30 (60%), and splenomeagly in 29 (58%). The most common cause was infection, followed by leukaemia and megaloblastic anaemia. Scrub typhus was the most prevalent infection found in this investigation.

Author(S) Details

Pankaj Katoch
Department of Microbiology, IGMC, Shimla, India.

Vipin Roach
Department of Pediatrics, IGMC, Shimla, India.

Surinder Singh
Department of Pediatrics, IGMC, Shimla, India.


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