Determining the Secondary Role of UV Light in Swimmers Melanoma Genesis | Chapter 7 | New Visions in Biological Science Vol. 8

 Swimmers are more likely than non-swimmers to develop cutaneous melanoma. UV exposure is the sole cause of cutaneous melanomas in swimmers, according to experimental research. The incidence of hydrogen peroxide (H2O2) breakdown in hair follicles has been proposed by several authors as an etiological component. Keratinocytes produce H2O2, which diffuses into melanocytes and may have a role in the aetiology and pathophysiology of cutaneous melanoma. Other in vitro studies suggest that exogenous H2O2 can reach water-submerged hairs at places like the infundibulum and injured hair follicles. The energy released by catalase during the eukaryotic cell's breakdown of H2O2 has also been suggested as a factor in cancer growth. According to epidemiological studies, consumption of the seaweed Sargasum filipendula, which has antiproliferative and antioxidant properties, has been related to a decreased incidence of Melanoma genesis in countries like Japan. According to this study, H2O2 appears to be the missing attributable risk in swimmers' cutaneous melanomas.

Methods: A literature review was conducted with the goal of identifying exogenous H2O2 as a major element in the development of Melanoma in cutaneous swimmers.

H2O2 is identified as a critical component for cutaneous melanoma in all published hypotheses and actual in vitro tests in Swimmers. The hair shaft/skin junction and areas where the external follicular wall has been weakened by injury are two places where exogenous H2O2 can enter the human hair follicle in water-submerged hairs.

Conclusion: According to published data, swimmers have a greater incidence of cutaneous melanomas than the overall population. In fresh or salt water bodies, H2O2 is formed by the conversion of dissolved organic matter by UV light from the sun. Spontaneously entering the hair follicles in swimmers. Melanoma tumour cells are created as a result of catalase degradation of H2O2, and the malignant cells spread into adjacent tissues, according to the theory. The sun's UV rays are assumed to play a secondary effect, with H2O2 being the predominant risk factor.

Author(S) Details

Abraham A. Embi
Citizen Scientists (CS), Miami, Florida, USA.

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