Fast dissolving films are now favoured over traditional tablets and capsules for disguising the taste of bitter medications and increasing patient compliance. When placed on the tongue, fast dissolving films consist of a very thin oral strip that dissolves in less than one minute. The purpose of this study is to create captopril mouth dissolving films and assess the effects of various formulation parameters on the films' physical and mechanical properties, as well as drug release behaviour. The film forming polymer was hydroxypropyl methyl cellulose (HPMC E15 and K4M) in various grades. In addition, the discussion goes over the various manufacturing procedures for film preparation. The disintegration times of formulations were found to be in the range of (52 2.5 to 125.6 2.02 s). Formula F2 had the quickest in vitro disintegration time (52 2.5 s) and was found to be suitable for film production due to its perfect physicochemical properties, rapid disintegration, and optimal in vitro release. It is possible to conclude that the solvent casting method can be used to produce captopril mouth dissolving films with a higher dissolution rate and better patient compliance.
Author(S) Details
V. T. Iswariya
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.
P. Deepika
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.
Sowjanya Battu
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.
View Book:- https://stm.bookpi.org/CAPRD-V7/article/view/5416
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