From a biological standpoint, alpha-2-macroglobulin's potential to generally suppress proteases in chronic and neuropathic pains, as well as inflammatory joint disorders, showed promise. Nerve damage and inflammation cause the release of cytokines. As a result of the inflammation, axonal damage and neuropathic symptoms may occur. Intradiscal autologous A2M injection indicated clinical improvements in a degenerative disc disease where the cartilage degradation product, the Fibronectin-Aggrecan complex (FAC), was discovered, albeit more research is needed to achieve consistent outcomes. Pro-inflammatory cytokines such as IL-1, IL-6, and TNF were found to be elevated during inflammation not only in peripheral nerves but also in inflammatory joint problems, cardiovascular events, and athrosclerosis events. It's worth noting how this could be used to treat inflammation, neuropathic pains, and other inflammatory conditions.
Author(S) Details
Jeimylo C. de Castro
Department of Physical Medicine and Rehabilitation, The Medical City-South Luzon, Sta Rosa City, Philippines and SMARTMD Philippines, Makati, Philippines.
View Book:- https://stm.bookpi.org/IDMMR-V2/article/view/5432
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