Currently, humans are infected with SARS-CoV-2, a highly contagious virus with great transmission ability, infection, and a high fatality rate, particularly among the elderly. Fever, sore throat, pneumonia, cough, headache, diarrhoea, muscle discomfort, shortness of breath, renal failure, and even death are common signs of the condition. All research efforts are focused on developing a medication or vaccine that will save the lives of millions of people; some have been successful and are currently being used in some nations. Medicinal plants are a green treasure trove of abundant primary and secondary metabolites with powerful biological activity. Secondary metabolites, such as alkaloids, flavonoids, tannins, and terpenoids, have a long history of antiviral activity. Inhibition of viral attachment to/penetration of the host cell; inhibition of virus replication; suppressing RNA replication; down regulation of viral proteins translation; interfering with virus non-structural/structural protein; down regulation of virus-induced pro-inflammatory/inflammatory signalling pathways in the host cell; and antioxidant activity, all of which reduce the virus-induced oxidative stress effect. There are currently attempts to use the power of nature while we are enslaved by a virulent virus. As a result, the primary goal of this review is to discuss various medicinal plants or their derivatives that can reduce the virus's virulence or ameliorate its symptoms.
Author(S) Details
Salama M. El-Darier
Botany and
Microbiology Department, Faculty of Science, Alexandria University, 21500,
Alexandria, Egypt.
Suzan A. Rashed
Botany and Microbiology Department, Faculty of Science, Alexandria
University, 21500, Alexandria, Egypt and Biotechnology Program, Basic and
Applied Sciences (BAS) Institute, Egypt-Japan University of Science and
Technology (E-JUST), New Borg El-Arab city, Alexandria, Egypt.
Ayat Fayez
Biotechnology Program, Basic and Applied Sciences (BAS) Institute,
Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab
city, Alexandria, Egypt.
Sarah S. Hassanein
Biotechnology Program, Basic and Applied Sciences (BAS) Institute,
Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab
city, Alexandria, Egypt and Department of Zoology, Faculty of Science, Cairo
University, 12613, Giza, Egypt.
Muhammed R. Sharaby
Botany and Microbiology Department, Faculty of Science, Alexandria University,
21500, Alexandria, Egypt and Biotechnology Program, Basic and Applied Sciences
(BAS) Institute, Egypt-Japan University of Science and Technology (E-JUST), New
Borg El-Arab city, Alexandria, Egypt.
Noran M. Tawfik
Biotechnology Program, Basic and Applied Sciences (BAS) Institute,
Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab
city, Alexandria, Egypt and Department of Zoology, Faculty of Science, Suez Canal
University, 41522, Ismailia, Egypt.
Heba Mansour
Biotechnology Program, Basic and Applied Sciences (BAS) Institute,
Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab
city, Alexandria, Egypt and Polymeric Materials Research Department, Advanced
Technology and New Materials Research Institute (ATNMRI), City of Scientific
Research and Technological Applications (SRTA-City), 21934, New Borg El-Arab
City, Alexandria, Egypt.
Mohamed Adel
Biotechnology Program, Basic and Applied Sciences (BAS) Institute,
Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab
city, Alexandria, Egypt and Department of Botany and Microbiology, Faculty of
Science, Helwan University, Cairo, 11790, Egypt.
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