Recent Trends of Gram-negative Bacteremia in a State of North India, the Forthcoming Challenges IGMC Shimla, India | Chapter 06 | Innovations in Microbiology and Biotechnology Vol. 3

 Background: Vascular endothelial dysfunction is important in the progression of sepsis because it causes an increase in vascular permeability, which leads to coagulation abnormalities and subsequent organ failure [1]. Bloodstream infections (BSI) are a leading source of life-threatening complications in people of all ages, but they are especially dangerous in the elderly. BSIs have also been linked to higher rates of hospitalisation, longer stays, and higher hospital expenditures, putting a financial strain on patients and their families. Antibiotic use is linked to bacteremia, septicemia, and death for a variety of reasons. Gram-negative bacteria are becoming increasingly resistant to antimicrobial therapy as a result of a variety of factors. The incidence and aetiology of Gram-Negative bacterial isolates, as well as their clinical importance, are reported in this study from our tertiary care institute in the northern part of India.

Materials and Methods: A one-year prospective observational study was undertaken in the Department of Microbiology at IGMC Shimla to determine the incidence, aetiology, and antibiotic resistance profile of Gram-negative bacterial isolates. All of the blood cultures were kept for at least 5 days in the Bactec bd fx system before being declared sterile.

Results: Gram-negative bacteria were found in 931 (73.02 percent) of the 1275 cultures that tested positive for bacteria. The Non-fermenter group of organisms was recovered in 292 (31.36%) of the 931 cultures that were positive for Gram-negative bacteria, followed by E. coli (266). (28.57 percent ). A maximum of 335 (35.98 percent) of the 931 cultures positive for GNB belonged to children aged 0 to 1. There were 574 males (61.65 percent) and 357 females (38.35 percent) among them.

Conclusion: Among Gram-negative isolates, the nonfermenter group was the most common. When compared to other age groups, infants were more likely to be positive. Among gram-negative isolates, males were more likely to be culture positive than females.

Author(S) Details

Pankaj Katoch
Department of Microbiology IGMC Shimla, India.

Anil Kanga
Department of Microbiology, Government Medical College, Nahan, India.

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