Diabetes mellitus and its complications are quickly becoming one of the world's most serious health issues. Diabetic nephropathy is now the leading cause of kidney failure. Because the majority of diabetic patients have poor control of their raised blood glucose and are particularly susceptible to serious macrovascular and microvascular consequences, the goal of diabetes treatment is to keep blood glucose levels close to normal. Toll-like receptors are transmembrane proteins that operate as a component in the immune response by transferring antigen recognition information from the outside to the interior of the cell. Insulin resistance, diabetic nephropathy, and atherosclerosis are all linked to the activation of the innate immune system via toll-like receptors (TLRs). Notch appears to be important in determining proximal epithelial destiny during nephronsegmentation as well as the differentiation of main cells in the renal collecting system, according to recent research. In the adult kidney, Notch signalling is significantly diminished; nonetheless, enhanced Notch signalling has been shown in both acute and chronic kidney injury. Albuminuria and glomerulosclerosis have been linked to increased glomerular epithelial Notch signalling, whereas tubular epithelial Notch activation has been linked to the development of fibrosis, most likely due to an incorrect epithelial repair mechanism. As a result, recent research suggests that Notch is an important regulator of kidney development, repair, and injury.
Author(s) Details
Najah R. Hadi
Faculty of Medicine, University of Kufa, Iraq.
Saad Rasool Shaker
Alzahra Teaching Hospital, Alnajaf Health Directorate, Iraq.
View Book:- https://stm.bookpi.org/DNRTRNP/article/view/5341
No comments:
Post a Comment