One Idea for Preparation of Solidified Oxide Eutectic Film by Controlling Chemical Reaction between the Melt and Substrate | Chapter 7 | Chemical and Materials Sciences: Developments and Innovations Vol. 10

A preparation method for solidified eutectic film with good adhesion between the film and substrate by controlling the chemical reaction between the base material and the melt is described. As an example, Al₂O₃-HfO₂ eutectic solidification film was formed on a SiC substrate. Al₂O₃-HfO₂ eutectic EBC film is prepared by the optical zone melting method on the silicon carbide substrate. At high temperatures, a small amount of silicon carbide decomposes into silicon and carbon. The components of Al₂O₃ and HfO₂ in the molten phase also react with the free carbon. The Al₂O₃ phase reacts with free carbon, leading to the formation of AlO vapor species. The composition of the molten phase becomes HfO₂ rich from the eutectic composition. HfO₂ phase also reacts with the free carbon and HfC phase is formed on the silicon carbide substrate; then a high-density intermediate layer is formed. The adhesion between the intermediate layer and the substrate is excellent by an anchor effect. When the solidification process is finished before all of the HfO₂ phase is reduced to the HfC phase, HfC-HfO₂ functionally graded layer is formed on the silicon carbide substrate and the Al₂O₃-HfO₂ eutectic structure grows from the top of the intermediate layer. This process can be applied to different oxide eutectic systems that include HfO₂ and/or ZrO₂ phase such as CaZrO₃-ZrO₂ and Ln₂Zr₂O₇-ZrO₂ eutectic systems.

 

Author (s) Details

 

Kyosuke Seya
College of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan.

 

Shunkichi Ueno
College of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan.

 

Byung-Koog Jang
National Institute for Materials Science, Tsukuba, Ibaraki 305-0047, Japan.

 

Please see the book here:- https://doi.org/10.9734/bpi/cmsdi/v10/4326

Formulation and Evaluation of Captopril Mouth Dissolving Film: A Recent Study | Chapter 07 | Current Aspects in Pharmaceutical Research and Development Vol. 7

 Fast dissolving films are now favoured over traditional tablets and capsules for disguising the taste of bitter medications and increasing patient compliance. When placed on the tongue, fast dissolving films consist of a very thin oral strip that dissolves in less than one minute. The purpose of this study is to create captopril mouth dissolving films and assess the effects of various formulation parameters on the films' physical and mechanical properties, as well as drug release behaviour. The film forming polymer was hydroxypropyl methyl cellulose (HPMC E15 and K4M) in various grades. In addition, the discussion goes over the various manufacturing procedures for film preparation. The disintegration times of formulations were found to be in the range of (52 2.5 to 125.6 2.02 s). Formula F2 had the quickest in vitro disintegration time (52 2.5 s) and was found to be suitable for film production due to its perfect physicochemical properties, rapid disintegration, and optimal in vitro release. It is possible to conclude that the solvent casting method can be used to produce captopril mouth dissolving films with a higher dissolution rate and better patient compliance.

Author(S) Details

V. T. Iswariya
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.

P. Deepika
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.

Sowjanya Battu
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.

View Book:- https://stm.bookpi.org/CAPRD-V7/article/view/5416