Formulation and Evaluation of Novel Mouth Dissolving Film of Tofacitinib Citrate by Using 32 Full Factorial Design | Chapter 1 | Advanced Concepts in Pharmaceutical Research Vol. 1

 Objective: The aim of the study was to design and judgment of mouth annulling oral films of tofacitinib citrate admitting fast reproducible drug dissolution in oral crater thus avoiding the first-pass metabolism to embellish the patient convenience.Method: Films has existed prepared by stable casting method by using Polymer and Plasticizers.Results: The results of prepared film pH, Thickness, Folding Endurance, Disintegration opportunity, drug content was found in the acceptable range.Conclusion: The present study shown that the MDFs of Tofacitinib maybe successfully planned by solvent calculating technique. Further, it was decided that formulation F3 and F6 containing 45% w/w and 50% w/w of polymer aggregation respectively were raise to be bearing satisfactory physicochemical and machinelike properties. Also, the support study of these two optimized formulations habitual the longer shelf life of MDFs.

Author(s) Details:

Meghana Raykar,
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

Malarkodi Velraj,
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/ACPR-V1/article/view/12072

Formulation and Evaluation of Captopril Mouth Dissolving Film: A Recent Study | Chapter 07 | Current Aspects in Pharmaceutical Research and Development Vol. 7

 Fast dissolving films are now favoured over traditional tablets and capsules for disguising the taste of bitter medications and increasing patient compliance. When placed on the tongue, fast dissolving films consist of a very thin oral strip that dissolves in less than one minute. The purpose of this study is to create captopril mouth dissolving films and assess the effects of various formulation parameters on the films' physical and mechanical properties, as well as drug release behaviour. The film forming polymer was hydroxypropyl methyl cellulose (HPMC E15 and K4M) in various grades. In addition, the discussion goes over the various manufacturing procedures for film preparation. The disintegration times of formulations were found to be in the range of (52 2.5 to 125.6 2.02 s). Formula F2 had the quickest in vitro disintegration time (52 2.5 s) and was found to be suitable for film production due to its perfect physicochemical properties, rapid disintegration, and optimal in vitro release. It is possible to conclude that the solvent casting method can be used to produce captopril mouth dissolving films with a higher dissolution rate and better patient compliance.

Author(S) Details

V. T. Iswariya
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.

P. Deepika
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.

Sowjanya Battu
Department of Pharmaceutics CMR College of Pharmacy, Hyderabad, Telangana, India.

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Study on the Development and Evaluation of a Novel Modified Release Pellet-based System for the Delivery of Desloratadine and Pseudoephedrine Hydrochloride | Chapter 5 | Trends in Pharmaceutical Research and Development Vol. 6

 Desloratadine and pseudoephedrine hydrochloride with different release profiles were prepared in a modified-release multiple unit dosage form (MRMUD). The MRMUD system consisting the immediate-release pellets of desloratadine and sustained release pellets of pseudoephedrine hydrochloride was formulated by using solution layering technique. To optimise the sustained release formulation, a 32 full-factorial configuration was used where the polymer ratio (Ethyl cellulose: hydroxyl propyl methyl cellulose) (X1) and percent polymer coating (X2) were taken as independent variables and the sum of drug release was taken as the dependent variables in 0.1N HCl (Y1) after 10 hrs (Y2). The Design Expert Software was used to carry out optimization studies. For in vitro release studies, formulations were evaluated; the release data was evaluated using the PCP Disso software using the model-dependent (curve fitting) approach. The in vitro drug release followed the Hixson-Crowell model and an anomalous or non-fickian form was found to be the drug release mechanism. Proper combination of ethyl cellulose and hydroxy propyl methyl cellulose polymer, percent polymer coating and process parameters have been found to provide a continuous 12-hour release of pseudoephedrine hydrochloride. The statistical approach to optimization of formulation is a useful tool, particularly when several variables are evaluated simultaneously. The responses observed were in close agreement with the expected values of the optimised formulations, demonstrating the feasibility of the optimization process in the production of the formulation of sustained releases.

Author (s) Details

Mr. Sachin U. Kushare
Department of Pharmaceutics, P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044, Maharashtra, India.

Dr. Atul A. Phatak
Department of Pharmaceutics, P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044, Maharashtra, India.

Dr. Praveen D. Chaudhari
Department of Pharmaceutics, P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044, Maharashtra, India.

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Studies on the Formulation of Sustained Release Zolpidem Tartrate Matrix Tablets through Optimization and Their Evaluation | Chapter 7 | Current Perspectives on Chemical Sciences Vol. 2

 The goal of the present study was to establish a method of sustained release of the hypnotic agent zolpidem, which is useful in the treatment of insomnia. The least complicated system for preserving the release of drug candidates is the Matrix tablet. Two HPMCK4 M and HPMCK15 M polymers were chosen to maintain the release for up to 12 hours. To optimise varied response variables, viz., release rate exponent (n), t50 percent, k, amount of drug released in 12 h and mean dissolution period, optimization techniques using factorial architecture for two factors at three levels (32) were selected. To measure the release kinetics, Zorel software was used.The programme for the design expert was used to create ANOVA for selected five Responses In addition, in vitro and in vivo experiments with newly developed sustained-release zolpidem tablets were conducted and compared to traditional marketed tablets (zoldem). In vivo rabbit investigations have shown a sustained release pharmacokinetic profile of zolpidem from matrix tablets formulated using HPMCK4 M and HPMCK15 M combinations. In conclusion , the results indicate that the sustained-release matrix tablets produced could provide a reasonably controlled release of zolpidem tartrate for up to almost 12 hours. The successful design, production and optimization of the formulation of zolpidem tartrate matrix tablets was conclusively achieved in the current study.

Author(s) Details

Dr. Masheer Ahmed Khan
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, M.P., India.

Prof. S. C. Chaturvedi
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, M.P., India.

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