The goal of the present study was to establish a method of sustained release of the hypnotic agent zolpidem, which is useful in the treatment of insomnia. The least complicated system for preserving the release of drug candidates is the Matrix tablet. Two HPMCK4 M and HPMCK15 M polymers were chosen to maintain the release for up to 12 hours. To optimise varied response variables, viz., release rate exponent (n), t50 percent, k, amount of drug released in 12 h and mean dissolution period, optimization techniques using factorial architecture for two factors at three levels (32) were selected. To measure the release kinetics, Zorel software was used.The programme for the design expert was used to create ANOVA for selected five Responses In addition, in vitro and in vivo experiments with newly developed sustained-release zolpidem tablets were conducted and compared to traditional marketed tablets (zoldem). In vivo rabbit investigations have shown a sustained release pharmacokinetic profile of zolpidem from matrix tablets formulated using HPMCK4 M and HPMCK15 M combinations. In conclusion , the results indicate that the sustained-release matrix tablets produced could provide a reasonably controlled release of zolpidem tartrate for up to almost 12 hours. The successful design, production and optimization of the formulation of zolpidem tartrate matrix tablets was conclusively achieved in the current study.
Author(s) Details
Dr. Masheer Ahmed Khan
School of Pharmacy, Devi Ahilya
Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, M.P., India.
Prof. S. C. Chaturvedi
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa
Road, Indore, M.P., India.
No comments:
Post a Comment