Context: Endothelin (ET)-1, a circulatory protein, and its receptors (ETA and ETB) have been reported to play a pivotal role in several diseases, including obesity, in different species. The research is intended to observe the extent of ET-1 circulatory and ETA/ETB expression in obese ventricles and kidneys compared to non-obese Wistar rats. Methods: obese groups at 14 and 34 weeks Wistar rats were compared at equivalent ages with non-obese controls. The ventricle and kidney circulatory ET-1, ETA and ETB concentrations were calculated by the Enzyme Associated Immunosorbent Assay (ELISA) technique following the conclusion of the two groups at weeks 14 and 24.
Results: The amount of circulatory ET-1, kidney and LDL
expression of ETA and ETB in obese rats was significantly higher than that of
control rats (T-test, P<0.05) in the elderly, with no discrepancies between
ETA and ETB in the ventricle. No variations in circulatory ET-1, ETA and ETB
expression levels were observed between the obese and younger rat control
groups (P>0.05). HDL levels for both groups were below normal value.
Conclusion: Obesity in obese elderly rats contributes to kidney vessel
dysregulation due to ET-1 and ETA/ETB operation.
Author
(s) Details
Assistant
Professor Irfan Idris
Department of Physiology, Medical Faculty,
Hasanuddin University, Indonesia.
Andi Wardihan Sinrang
Department of Physiology,
Medical Faculty, Hasanuddin University, Indonesia.
Aryadi Arsyad
Department of Physiology, Medical Faculty, Hasanuddin University,
Indonesia.
Syafrudin Alwi
Department
of Physiology, Medical Faculty, Hasanuddin University, Indonesia.
Muhammad Isman Sandira
Department of Physiology, Medical Faculty, Hasanuddin University,
Indonesia.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/288
No comments:
Post a Comment