A
novel sequence of substituted aryl ethynyl integrated quinazolines (11a-j) were
designed and synthesised and 1HNMR, 13CNMR, and mass spectral analysis
characterised their structures. In addition, these compounds were tested
against human cancer cell lines such as MCF-7 (human breast cancer), A549
(human lung cancer), DU-145 (human prostate cancer) and MDA MB-231 (human
breast cancer) for their preliminary anticancer activity. Four compounds (11b,
11c, 11d and 11 g) were shown to have more potent activity of all compounds
than etoposide.
Author(s) Details
Pruthu Kalaa
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar,
Andhra Pradesh, 522510, India.
Dittakavi
Ramachandrana
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/318
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