In
recent years, green synthesis of organic compounds using solvent-free
conditions has gained popularity, as most solvents are either poisonous or
flammable. In the field of natural and synthetic organic chemistry,
dihydropyrimidinones are very significant heterocyclic motifs. The natural acid
catalyst is used for organic synthesis, which catalyses different organic
transformations efficiently. A green methodology for the synthesis of the
dihydropyrimidinone derivative is the objective of the present study. The
present study focuses on the synthesis, characterization and biological
evaluation of vanillin, ethylacetoacetate and urea derivatives of
dihydropyrimidinone
ethyl-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
using gooseberry extract. The antimicrobial activity indicates that the
synthesised dihydropyrimidinone can be used to treat microbial diseases. The
synthesised compound is characterised by spectroscopy of UV-Visible and FT-IR.
Antibacterial , antifungal, antioxidant and anti-helminthic activities are seen
in the synthesised compound. This natural acid catalysed synthesis is safe,
environmentally friendly and does not use hazardous materials and quantifies it
as a green approach to organic compound synthesis.
Author(s) Details
Dr. Sheeba Daniel
Department of Chemistry and Research Centre, Holy Cross College
(Autonomous), Nagercoil- 629004, Tamil Nadu, India.
K.
Saraniya
Department of Chemistry and Research Centre, Holy Cross College
(Autonomous), Nagercoil- 629004, Tamil Nadu, India.
P.
Vinitha
Department of Chemistry and Research Centre, Holy Cross College
(Autonomous), Nagercoil- 629004, Tamil Nadu, India.
T.
R. Scotlin Blessy
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/318
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