Background: Much attention has recently been paid
to calcium phosphate cements (CPCs) because of their advantages in terms of in
situ handling and forming capabilities compared to calcium phosphate
bioceramics. Mechanical and in vitro biological physicochemical properties of
novel polymeric calcium phosphate cement (CPC) formulations have been
investigated.
Methods: to obtain Forms I,
II and III CPCs, monocalcium phosphate, calcium oxide and synthetic
hydroxyapatite were mixed either with modified polyacrylic acid, light
activated polyalkenoic acid or with polymethyl vinyl ether maleic acid. CPCs
were compared with zinc polycarboxylate cement (control) setting time,
compressive and diametric strength. X-ray diffraction, scanning electron
microscopy, and infrared spectroscopy were used to identify specimens. CPCs and
control were tested for in vitro cytotoxicity.
Results: Hydroxyapatite,
monetite, and brushite were seen by X-ray diffraction analysis. The presence of
stretching peaks in the IR spectra of set cements confirmed the acid-base
reaction. Rod-like crystals and platy crystals were disclosed by SEM. The
cement setting time was 5-12 min. Compared with power, type III showed
significantly higher strength values. High biocompatibility was achieved in type
III.
Conclusions: In comparison to zinc polycarboxylate cement (control group), Type
III CPC displayed acceptable setting time, substantially higher compressive,
and diametral tensile strengths. For dental applications, Type III CPCs show
promise.
Author(s) Details
Rania M. Khashaba
Department
Oral Biology, Medical College of Georgia, Augusta, GA 30912-1129, USA.,
Department Orthopaedic Surgery, Section of Biomaterials, Medical College of
Georgia, Augusta, GA 30912-1129, USA. and Department of Dental Materials, Misr
International University (MIU), Cairo 11787, Egypt.
Mervet Moussa
Department
of Oral Pathology, Cairo University, Cairo 11559, Egypt. and Department of Oral
Pathology, Misr International University (MIU), Cairo 11787, Egypt.
Christopher Koch
Department
Orthopaedic Surgery, Section of Biomaterials, Medical College of Georgia,
Augusta, GA 30912-1129, USA.
Arthur R. Jurgensen
Savannah
River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808,
USA.
David M. Missimer
Savannah
River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808,
USA.
Ronny L. Rutherford
Savannah
River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808,
USA.
Norman B. Chutkan
Department Orthopaedic Surgery, Section of
Biomaterials, Medical College of Georgia, Augusta, GA 30912-1129, USA.
James L. Borke
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