A Combination Therapy for Diabetes Miletus Using Metformin Hydrochloride and Gliclazide Bilayer Tablets | Chapter 3 | Pharmaceutical Research - Recent Advances and Trends Vol. 4

 

Objective: The main objective of the present investigation is to develop combination therapy for Type II Diabetic subjects using bilayer sustained release formulation of metformin hydrochloride (MFH) and gliclazide (GLZ) based on monolithic-matrix technology.

 

Methods: Bilayer tablets were prepared by the wet granulation method. Initially, metformin HCl layer and gliclazide layers were optimized using release retardants like Polyox WSR coagulant and different viscosity grades of hydroxyl propyl methyl cellulose (HPMC) and evaluated for in vitro dissolution performance and drug excipient studies separately. The optimized formulations were selected and compressed to bilayer tablets to achieve the desired sustained release in combination.

 

Results: Metformin hydrochloride and gliclazide showed sustained release of drug by diffusion mechanism and followed first-order kinetics. The best formulation of metformin hydrochloride (M7) and gliclazide (G8) shows 99.93% and 99.65% of drug release in 24 h respectively. The similarity factor (f2) was 89.95 for metformin hydrochloride and 83.62 for gliclazide when compared to the innovator. FTIR studies reveal the absence of significant interactions indicating drug excipient compatibility.

 

Conclusion: The monolith diffusion-controlled bilayer tablets of metformin hydrochloride and gliclazide offer improved patient compliance and convenience with better postprandial hyperglycemic control with once-a-day dosing. The sustained release of the drug up to 24 h regulates antidiabetic activity round the clock with minimal side effects.

 

Author(s) Details

Rajeswari Aleti
Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Hyderabad 500090, India.

Sailaja Gunnam
Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Hyderabad 500090, India.

Monika Nijhawan
Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Hyderabad 500090, India.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v4/1115

Advance Assessment of Pharmaceutical Mini-tablets | Chapter 7 | Pharmaceutical Research: Recent Advances and Trends Vol. 10

The most generally used method of administration is oral, and different age groups employ different solid oral dosage forms, particularly tablets. Mini tablets for pharmaceutical use have a diameter of 1-4 mm. Mini tablets are more convenient to make than pellets and come in many unit dosage formats. There are numerous varieties of mini-tablets available, including oral disintegrating mini-tablets, gastro-retentive mini-tablets, pH-responsive mini-tablets, bio-adhesive mini-tablets, and pediatric mini-tablets. This dose type primarily lessens subject variation. The review includes information on the benefits of mini-tablets, their varieties, their production process and related difficulties, coatings for mini-tablets, and mini-tablet evaluation.

 

Author (s) Details

 

HimansuRanjan Palatasingh
Department of Pharmaceutics, College of Pharmaceutical Sciences, Puri (Affiliated to BPUT & OUHS), Baliguali, Puri-Konark Marine Drive Road, Puri, Odisaha-752004, India.

 

ChinmayaKeshari Sahoo
Department of Pharmaceutics, College of Pharmaceutical Sciences, Puri (Affiliated to BPUT & OUHS), Baliguali, Puri-Konark Marine Drive Road, Puri, Odisaha-752004, India.

 

Amiyakanta Mishra
Department of Pharmaceutics, College of Pharmaceutical Sciences, Puri (Affiliated to BPUT & OUHS), Baliguali, Puri-Konark Marine Drive Road, Puri, Odisaha-752004, India.

 

Ch. NiranjanPatra
Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Brahmapur, Odisha-760010, India.

 

B.Ray
Department of Pharmaceutics, College of Pharmaceutical Sciences, Puri (Affiliated to BPUT & OUHS), Baliguali, Puri-Konark Marine Drive Road, Puri, Odisaha-752004, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v10/3413

An Overview on Sintering Technique in Pharmaceutical Sciences | Chapter 11 | Advanced Concepts in Pharmaceutical Research Vol. 9

 Sintering is the mechanism that strengthens the mechanical properties of consolidated pharmaceutical powders at high temperatures, forms solid bonds during tablet compression, and causes thermal curing in polymer-latex film coatings, according to pharmaceutical science. The concept of sintering was applied in the investigation of the effect of heating on the mechanical properties of pharmaceutical powders. The formation of solid bonds within a powder bed during tablet compression was studied in terms of sintering. The sintering process has been used for the fabrication of sustained–release matrix tablets and for the stabilization of the drug permeability of film coatings derived from various pharmaceutical lattices.  Drug release characteristics from the sintered matrix tablets were inversely related to the sintering temperature and sintering duration. As the temperature of sintering and duration of sintering increased, the time required to attain maximum release from tablets also increased accordingly. The changes in the microstructures, hardness, friability, wettability, disintegration time and dissolution rate of tablets stored at elevated temperatures were also described as a result of sintering. Sintering conditions markedly affected the drug release properties depending upon the duration and temperature of sintering. The use of this sintering technique adds to the effectiveness of polymers for controlling drug release and provides a significant and expedient method for control release in oral dosage form.

Author(s) Details:

Dr. Chandan Mohanty
Guru Nanak Institutions Technical Campus-School of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Telangana, India.

Mrs. Soumya Stuti Patnaik
Guru Nanak Institutions Technical Campus-School of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Telangana, India.

Please see the link here: https://stm.bookpi.org/ACPR-V9/article/view/14370

Studying Formulation and Physicochemical Characterization of Buccal Mucoadhesive Films Containing Alfuzosin Hydrochloride | Chapter 7 | Technological Innovation in Pharmaceutical Research Vol. 1

The physiology of the mouth has allowed many drugs to be administered through the oral route. Another promising method for drug delivery is oral mucosal drug delivery, which has a range of advantages. The aim of this study was to embed a drug molecule, alfuzosin hydrochloride, in a sustained release buccal film for an 8-hour duration in order to prevent first-pass metabolism and increase bioavailability. Materials and Methods: In this research, sustained release formulations of alfuzosin hydrochloride buccoadhesive films were developed using the polymers HPMC, K100M, sodium alginate, and chitosan, and the prepared buccoadhesive films were systematically evaluated in vitro. To achieve a unidirectional release pattern, the films were given a backing layer of Eudragit RS100. Weight, thickness, material uniformity, folding durability, bioadhesive ability, surface pH, in vitro drug release, and ex vivo buccal permeation tests were all used to test the films. The solvent-cast films had a smooth and elegant look, were uniform in thickness, weight, and drug content, and had strong folding endurance. The formulations were found to be solid but not brittle based on mechanical properties. Different equations and kinetic models, such as zero order, first order, higuchi's plot, and peppas plot, were used to suit the in vitro release results. The formulation A7 had the best mucoadhesive efficiency and matrix mediated release (2 percent HPMC K100 M and 2 percent chitosan). The value of the correlation coefficient (r) suggests that the drug release kinetics is zero order. A stability analysis of optimised films was performed, and both drug and buccal films were found to be stable. Conclusion: The new buccal formulation appears to be an ideal system for increasing drug bioavailability by preventing hepatic first-pass metabolism. Alfuzosin hydrochloride buccoadhesive films optimised with HPMC and chitosan can meet the ideal requirements for oral buccoadhesive films, and a therapeutically effective amount of alfuzosin hydrochloride can be provided through sustained release.

Author (s) Details

Abikesh Prasada Kumar Mahapatra
OPJS University, School of Pharmacy, Churu, Rajasthan-331303, India.

Sonia P. Nagvenkar
VerGo Pharma Research Laboratories Pvt. Ltd., Verna, Goa-403107, India.

Rajashree Gude
Goa College of Pharmacy, Panaji, Goa-403107, India.

View Book :- https://stm.bookpi.org/TIPR-V1/issue/view/38

Studies on the Formulation of Sustained Release Zolpidem Tartrate Matrix Tablets through Optimization and Their Evaluation | Chapter 7 | Current Perspectives on Chemical Sciences Vol. 2

 The goal of the present study was to establish a method of sustained release of the hypnotic agent zolpidem, which is useful in the treatment of insomnia. The least complicated system for preserving the release of drug candidates is the Matrix tablet. Two HPMCK4 M and HPMCK15 M polymers were chosen to maintain the release for up to 12 hours. To optimise varied response variables, viz., release rate exponent (n), t50 percent, k, amount of drug released in 12 h and mean dissolution period, optimization techniques using factorial architecture for two factors at three levels (32) were selected. To measure the release kinetics, Zorel software was used.The programme for the design expert was used to create ANOVA for selected five Responses In addition, in vitro and in vivo experiments with newly developed sustained-release zolpidem tablets were conducted and compared to traditional marketed tablets (zoldem). In vivo rabbit investigations have shown a sustained release pharmacokinetic profile of zolpidem from matrix tablets formulated using HPMCK4 M and HPMCK15 M combinations. In conclusion , the results indicate that the sustained-release matrix tablets produced could provide a reasonably controlled release of zolpidem tartrate for up to almost 12 hours. The successful design, production and optimization of the formulation of zolpidem tartrate matrix tablets was conclusively achieved in the current study.

Author(s) Details

Dr. Masheer Ahmed Khan
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, M.P., India.

Prof. S. C. Chaturvedi
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshila Campus, Khandwa Road, Indore, M.P., India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/302