Formulation and Evaluation of Novel Mouth Dissolving Film of Tofacitinib Citrate by Using 32 Full Factorial Design | Chapter 1 | Advanced Concepts in Pharmaceutical Research Vol. 1

 Objective: The aim of the study was to design and judgment of mouth annulling oral films of tofacitinib citrate admitting fast reproducible drug dissolution in oral crater thus avoiding the first-pass metabolism to embellish the patient convenience.Method: Films has existed prepared by stable casting method by using Polymer and Plasticizers.Results: The results of prepared film pH, Thickness, Folding Endurance, Disintegration opportunity, drug content was found in the acceptable range.Conclusion: The present study shown that the MDFs of Tofacitinib maybe successfully planned by solvent calculating technique. Further, it was decided that formulation F3 and F6 containing 45% w/w and 50% w/w of polymer aggregation respectively were raise to be bearing satisfactory physicochemical and machinelike properties. Also, the support study of these two optimized formulations habitual the longer shelf life of MDFs.

Author(s) Details:

Meghana Raykar,
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

Malarkodi Velraj,
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/ACPR-V1/article/view/12072

Interaction of Movable Conjugations Friction Surfaces under "No-wear" Rubbing Conditions | Chapter 2 | Recent Progress in Science and Technology Vol. 9

 Experimental studies of disagreement and wear processes of copper alloy-gird pairs in glycerol in the dynamic of drifting distance 70 – 2100 meters are deliberate in this work. X-ray studies of the surface possessions changes during interplay of the triad of resistance are conducted. It is proved that micro absorbing and transfer of law enforcement officer alloy to the steel surface and nasty and mechanochemical wear of the antifriction alloy take place in the primary period of the policeman alloy – steel pair interplay. The results of X-ray and photoelectron spectroscopy studies of arrangement and thickness of the securing metal-holding films on the friction surfaces of law enforcement officer alloy – steel pairs are presented. It is shown that these guarding films on the resistance surfaces formed under “no-wear’’ stroking conditions show high microscopic organic compounds.

Author(s) Details:

Vladimir N. Malyshev,
National University of Oil and Gas “Gubkin University”, 65, Bld.1 Leninsky Prospect, Moscow, 119991, Russia.

Please see the link here: https://stm.bookpi.org/RPST-V9/article/view/10263