Study on Integrated Mitochondrial Function and Cancer-Related Fatigue in Men with Prostate Cancer Undergoing Radiation Therapy | Chapter 10 | Issues and Developments in Medicine and Medical Research Vol. 3

 Fatigue is one of the most prevalent symptoms that has the largest detrimental influence on quality of life in cancer patients, but it is also one of the least understood. The purpose of this study was to examine into changes in mitochondrial function and cancer-related fatigue in patients who were getting localised radiation therapy for non-metastatic prostate cancer (XRT).

We suggested a mitochondrial bioenergetic mechanism of radiation-induced fatigue that links defective oxidative phosphorylation (OXPHOS) via a complex III defect and ATP depletion as a result of XRT. In prostate cancer patients' peripheral blood mononuclear cells (PBMCs), integrated mitochondrial function was assessed as mitochondrial OXPHOS. The improved Piper Fatigue Scale was used to assess fatigue. Before (day 0) and after (day 21) XRT, data was collected.

At day 21 of XRT, fatigue symptoms worsened in 15 individuals with prostate cancer (p 0.05). At day 21, the rates of mitochondrial OXPHOS complex III-linked and uncoupled complex III in PBMCs were significantly lower than before XRT (p 0.05). Furthermore, a higher fatigue score was linked to a reduced OXPHOS complex III-linked respiration rate in people who had XRT.

Conclusion: At day 21 of XRT, 15 prostate cancer patients had a deficiency in oxidation commencing at complex III in their PBMC mitochondria. Complex III could be a target for pharmacological and, in particular, nutraceutical therapies in the development of CRF nursing interventions, such as coenzyme Q10.

Author(S) Details

Chao-Pin Hsiao
The Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.

Mei-Kuang Chen
Department of Psychology, University of Arizona, Tucson, AZ, USA.

Barbara Daly
The Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.

Charles Hoppel
Center for Mitochondrial Disease, Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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