Effect of Personalised Physiotherapy Protocol on Managing Fatigue, Anxiety and Depression during Radiotherapy for Oesophagal Squamous Cell Carcinoma: A Case Report | Chapter 1 | An Overview of Disease and Health Research Vol. 4

Squamous cell carcinoma of the oesophagus is the eighth most common cancer found in the world and is also one of the leading causes of death. In this condition, the squamous cells on the inner lining of the oesophagus divide uncontrollably, resulting in the narrowing of the lumen, leading to difficulties in swallowing and painful swallowing. A 35-year-old female patient diagnosed with squamous cell carcinoma of the oesophagus operated in who underwent a feeding jejunostomy, was admitted to the ward for chemoradiation therapy. The patient had complaints of fatigue and was also suffering from depression and anxiety. A personalised physiotherapy protocol was formed, which included general mobility, strengthening exercises, aerobic exercises, yoga, relaxation and recreational activities. The fatigue was assessed using the Functional Assessment of Chronic Illness Therapy- Fatigue (FACIT-F) subscale and the Hospital Anxiety and Depression Scale (HADS) was used to assess hospital-based depression and anxiety. This case study concluded that this personalised protocol was found to have positive effects on fatigue, depression and anxiety.

Author(s) Details

 Tushara Naira
College of Physiotherapy, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat 391760, India.

G. P. Kumarb
College of Physiotherapy, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat 391760, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/aodhr/v4/5769

Yoga Therapy: A Boon for People Living with Cancer | Chapter 9 | Disease and Health: Research Developments Vol. 9

Cancer is one of the most common causes of death worldwide. Most of the patients with cancer have to undergo a long-term treatment protocol which includes surgery, radiotherapy, and chemotherapy. Many complications result because of cancer and its treatment, like cancer pain, cancer-related fatigue, stress, anxiety, and depression. All these complications reduce the quality of life of the patients living with cancer. Yoga is an ancient Indian Science that works on the mind-body concept, helping to maintain homeostasis in the body by regulating the autonomic nervous system. It includes asanas, pranayamas, and meditation. This helps in reducing the cancer pain, fatigue, stress, anxiety, and depression. All these factors help in improving the Quality of Life and mortality of the cancer patients. This chapter mainly focuses on providing insights into how yoga therapy is helpful for people living with cancer. In conclusion, yoga therapy, which is focused on mind-body concepts, is very helpful in reducing pain, anxiety, depression, and fatigue in cancer patients. This, in turn, becomes helpful in improving the quality of life and mortality of cancer patients.

 

 

Author (s) Details

Tushara Nair
College of Physiotherapy, Sumandeep Vidyapeeth Deemed to be University, India.

 

G.P. Kumar
College of Physiotherapy, Sumandeep Vidyapeeth Deemed to be University, India.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v9/5208

Study on Integrated Mitochondrial Function and Cancer-Related Fatigue in Men with Prostate Cancer Undergoing Radiation Therapy | Chapter 10 | Issues and Developments in Medicine and Medical Research Vol. 3

 Fatigue is one of the most prevalent symptoms that has the largest detrimental influence on quality of life in cancer patients, but it is also one of the least understood. The purpose of this study was to examine into changes in mitochondrial function and cancer-related fatigue in patients who were getting localised radiation therapy for non-metastatic prostate cancer (XRT).

We suggested a mitochondrial bioenergetic mechanism of radiation-induced fatigue that links defective oxidative phosphorylation (OXPHOS) via a complex III defect and ATP depletion as a result of XRT. In prostate cancer patients' peripheral blood mononuclear cells (PBMCs), integrated mitochondrial function was assessed as mitochondrial OXPHOS. The improved Piper Fatigue Scale was used to assess fatigue. Before (day 0) and after (day 21) XRT, data was collected.

At day 21 of XRT, fatigue symptoms worsened in 15 individuals with prostate cancer (p 0.05). At day 21, the rates of mitochondrial OXPHOS complex III-linked and uncoupled complex III in PBMCs were significantly lower than before XRT (p 0.05). Furthermore, a higher fatigue score was linked to a reduced OXPHOS complex III-linked respiration rate in people who had XRT.

Conclusion: At day 21 of XRT, 15 prostate cancer patients had a deficiency in oxidation commencing at complex III in their PBMC mitochondria. Complex III could be a target for pharmacological and, in particular, nutraceutical therapies in the development of CRF nursing interventions, such as coenzyme Q10.

Author(S) Details

Chao-Pin Hsiao
The Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.

Mei-Kuang Chen
Department of Psychology, University of Arizona, Tucson, AZ, USA.

Barbara Daly
The Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.

Charles Hoppel
Center for Mitochondrial Disease, Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

View Book:- https://stm.bookpi.org/IDMMR-V3/article/view/5471