Estimation of Urinary Uranium and Urinary 8-OHdG Compound as Biomarker for Oxidative DNA Damage in Exposures and Non-Exposures Adult Healthy Groups in Najaf Governorate| Chapter 9 | Perspective of Recent Advances in Medical Research Vol. 8

 Environmental pollution accompanying many synthetic and material determinants influence people energy everywhere the realm. Najaf governorate of Iraq have organic and human fashioned soures of fallout. Increased number of malignancy cases, autoimmune ailment has happened written in the last few decades. The present study aims to evalute urinary uranium concentration and urinary aggregation of 8-OHdG compound as biomarker for oxidative DNA damage. In this study, a total of 88 athletic persons in Al-Najaf governorate were gathered as environmentally uranium uncoverings n=29 (G1), occupationally uncoverings n=27 (G2), and non-uranium uncoverings n=32 (G3). All groups were subject for guess of urinary uranium aggregation using CR-39 SSNTD arrangement, urinary 8-OHdG compound as a biomarker for oxidative DNA damage was supposed again utilizing Elisa method. Results presented that mean advantage of uranium aggregation were (1.836±0.426 µg/L), (2.02±0.404 µg/L) and (1.755± 0.437 µg/L) for group1, group2 and group3 individually, while the mean principles for 8-OHdG compound were (49.810±15.484 ng/ml), (47.717±14.232 ng/ml) and (46.769±14.249 ng/ml) for the three groups respectively. No meaningful mathematical dissimilarities were written betwixt all dossier got. The results submitted closeness of uranium contamination in all athletic groups containing non-uncovering (G3) as distinguished accompanying citation profit of (WHO, 2004). DNA damage erect further entirely groups according to 8-OHdG levels written. DNA oxidative damage can come from of uranium dirtiness written comprehensively healthful groups of Najaf governorate proven in the study.

Author(s) Details:

Dhuha S. Saleh,
Department of Biology, College of Science, University of Baghdad, Iraq.

Samia K. Abbas,
General Directorate of Education in Najaf Governorate, Iraqi Ministry of Education, Al-Aseel Central Preparatory for Girls, Iraq.

Hayder S. Hussain,
Department of Physics, College of Science, University of Baghdad, Iraq.

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