Therapeutic Drug Monitoring of Gentamicin in a Patient with Delayed Wound Healing | Chapter 6 | Perspective of Recent Advances in Medical Research Vol. 12

 Gentamicin, secondhand for the treatment of weighty gram-negative contaminations, has a narrow therapeutic index. This property can lead to various side effects, accordingly, therapeutic drug listening (TDM) is important in gentamicin therapy.This division aims to report the pharmacokinetics of gentamicin when using a previously-daily drug regimen.The patient, a 78-period-old male, weighed 78 kg and was 1.75 m tall. He was introduced into the hospital accompanying a wound infection provoked by chronic appendage ischaemia. A once-daily drug of gentamicin (360 mg by infusion over 30 record) in combination accompanying flucloxacillin was prescribed to this patient. A gentamicin ancestry sample was taken every day for four days: Day 1 = 1.4 mg/L, Day 2 = 2.1 mg/L, Day 3 = 2.1 mg/L, Day 4 = 1.6 mg/L. The patient’s antitoxin creatinine was 88 µmol/L during the four days. To decide the dosage and break for gentamicin administration, the Hartford nomogram was working. A once-day-to-day dosing regimen of gentamicin can bring about the clinical and bacteriological cure of contamination. In addition, the Hartford nomogram is a reliable finish for keeping path of gentamicin's once-daily application schedule.

Author(s) Details:

Saeed Fahad Algahtani,
Department of Clinical Pharmacy, Infectious Disease Pharmacist, Prince Sultan Armed Forces Hospital In Madinah, Saudi Arabia.

Fahad M. Alqahtani,
Drug Information and Poisoning Center, Al Kharj Military Industries Corporation Hospital, Saudi Arabia.

Mohammed Qahl,
Department of Pharmacy, Northern Area Armed Forces Hospital, Saudi Arabia.

Please see the link here: https://stm.bookpi.org/PRAMR-V12/article/view/9660