β-like Globin Gene Cluster Haplotypes in Sickle Cell Disease Patients in Odisha, India | Chapter 13 | Perspective of Recent Advances in Medical Research Vol. 11

 Though Sickle container disease (SCD) is innately characterised by a single point mutation, skilled are various modulators that influence the phenotype of this disease accompanying varying grades of clinical asperity. The most important phenotype modulators are HbF concentration, union of α-thalassemia, haplotype. SCA is associated with five "classic" haplotypes, each with different terrestrial distributions across different domains of the world. It has happened suggested that these haplotypes also influence HbF aggregation. Lowest HbF concentration is in the direction of Benin and Bantu haplotype and highest in Indian-Arab (AI) haplotype. Eight polymorphic sites inside the β-globin gene cluster (Xmnl Gγ, Hind-III Gγ, Hind-III Aγ, HincIl  ψβ, HincII 3’ ψβ, RsaI 5’β, AvaII β and HinfI 3’β) were resolved by Restriction Fragment Length Polymorphism (RFLP). We observed the closeness of Arab-Indian haplotype in all our samples.  We have also establish that 75.86% showed homozygous Arab-Indian culture followed by 24.14% heterozygous Arab-Indian population.

Author(s) Details:

Pulak Pritam,
AIPH University, Bhubaneswar, Odisha-751002, India and School of Applied Sciences, Kalinga institute of Industrial Technology, KIIT University, India.

Bimal Prasad Jit,
All India Institute of Medical Science, Ansari Nagar, New Delhi-110029, India.

Padmalaya Das,
AIPH University, Bhubaneswar, Odisha-751002, India.

Please see the link here: https://stm.bookpi.org/PRAMR-V11/article/view/9575