Detection of Ovarian Cancer: Combined Use of CA 125 and Inhibin as Tumor Marker | Chapter 1 | Research Highlights in Disease and Health Research Vol. 2

 The current study compares the efficiency of a combined test utilizing CA 125 and Inhibin for early detection of ovarian tumor to CA125 or Inhibin alone. Fifty daughters attending Gynae OPD accompanying clinical trace of ovarian malignancy were contained in the study. Prior to surgery, all of these mothers had their CA 125 and Inhibin levels measured. The verdicts showed that Out of 50 sufferers recruited, 30 (60%) were erect to have carcinoma ovary and 20 (40%) were establish to have benign ailments. Out of 30 cases of carcinoma ovary, CA125 was elevated in 81% of cases and Inhibin was raised in 78% of cases. CA 125 was erect to have a sensitivity of 90% and precision of 60% for detecting carcinoma ovary, accompanying a statistically significant certain predictive advantage of 77% and negative predictive worth of 80%.  The sensitivity and particularity of serum Inhibin for the alike were 86.6% and 20%, respectively. The definite and negative predictive principles were 61.9% and 50%, respectively, and were not statistically meaningful. The combined CA125 and Inhibin sense and specificity were 100% and 30%, individually. The positive and negative predicting principles were 68.1% and 100%, respectively, and were statically main. In comparison to CA125 or Inhibin used unique, the combination of CA125 and Inhibin has greater sensitivity and particularity in detecting ovarian cancer.

Author(s) Details:

Avinash P. Dubbewar,
Department of Obstetrics and Gynecology, AFMS, New Delhi, India.

Ravishekar N. Hiremath,
Department of Community Medicine, AFMS, New Delhi, India.

Kasi Viswanath,
Department of Community Medicine, AFMS, New Delhi, India.

Sandhya Ghodke,
Department of Anaesthesiology, Rainbow Children Hospital, Bangalore, India.

B. Pathak,
Department of Obstetrics and Gynecology, AFMS, New Delhi, India.

Manas Biswas,
Department of Obstetrics and Gynecology, AFMS, New Delhi, India.

Gunjan Malhotra,
Department of Obstetrics and Gynecology, AFMS, New Delhi, India.


Prathyusha Gouru,
Department of Obstetrics and Gynecology, AFMS, New Delhi, India

Preeti Yadav,
Department of Obstetrics and Gynecology, AFMS, New Delhi, India.

Please see the link here: https://stm.bookpi.org/RHDHR-V2/article/view/9610