Zein Nanoplatforms for Functional Promotion of Pro-apoptosis and Antiproliferation Induced in Human Breast Carcinoma MCF7 Cells by Pterostilbene | Chapter 8 | Perspective of Recent Advances in Medical Research Vol. 12

 The aim of current study search out investigate potential of PTS-ZN NSs formulation on lightening cytotoxicity, pro-apoptotic and oxidative stress potentials of PTS in MCF-7 containers. PTS-ZN NSs were synthesised using the liquid-liquid phase break-up method. The formulations grown were evaluated in terms of piece size analysis, encapsulation effectiveness, and in vitro spread. Cytotoxicity, uptake, cell era progression, Annexin-V assay, apoptotic genes mRNA expression, and biochemical assays were still performed. Five formulations of PTS-ZN NSs (P1-P5) were willing according to liquid–liquid phase break-up method to belittle the use of solvents. The study indicated that apoptosis in MCF-7 containers was confirmed and augmented through caspases reliant signaling pathways and restriction of CDK1 activity due to use of ZN-NSs in transmittal of PTS in comparison accompanying free PTS. Promising research outcomes included extreme EE% nanocomposites, 36 h extended PTS diffusion, a synergized cytotoxicity description, enhanced MCF-7 containers uptake, ameliorated apoptosis induced potential, reinforced mRNA expression of CASP3, CASP7 and CDK1 genes and important oxidative stress.

Author(s) Details:

Majid Mohammad Al-Sawahli,
Faculty of Pharmacy, Ahram Canadian University, 6th October City, Egypt, Department of Pharmaceutics, College of Pharmacy, The Islamic University, Najaf, Iraq and Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafr Elsheikh University, Kafr Elsheikh, Egypt.

Mohamed A. Zarka,
Department of Pharmacognosy, College of Pharmacy, The Islamic University, Najaf, Iraq.

Mowafaq Mohammed Ghareeb,
Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

Hussam Ibrahim Kutbi,
Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Ahmed Kamal Kammoun,
Faculty of Pharmacy, Ahram Canadian University, 6th October City, Egypt, Department of Pharmaceutics, College of Pharmacy, The Islamic University, Najaf, Iraq and Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafr Elsheikh University, Kafr Elsheikh, Egypt.

Ayman M. Noreddin,
Department of Pharmacy Practice, Faculty of Pharmacy, Ahram Canadian University, 6th October City, Egypt and Department of Internal Medicine, School of Medicine, University of California, Irvine, California, USA.

Dalia Farag A. El-Telbany,
Department of Pharmaceutics, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.

Please see the link here: https://stm.bookpi.org/PRAMR-V12/article/view/9662