Zein Nanoplatforms for Functional Promotion of Pro-apoptosis and Antiproliferation Induced in Human Breast Carcinoma MCF7 Cells by Pterostilbene | Chapter 8 | Perspective of Recent Advances in Medical Research Vol. 12

 The aim of current study search out investigate potential of PTS-ZN NSs formulation on lightening cytotoxicity, pro-apoptotic and oxidative stress potentials of PTS in MCF-7 containers. PTS-ZN NSs were synthesised using the liquid-liquid phase break-up method. The formulations grown were evaluated in terms of piece size analysis, encapsulation effectiveness, and in vitro spread. Cytotoxicity, uptake, cell era progression, Annexin-V assay, apoptotic genes mRNA expression, and biochemical assays were still performed. Five formulations of PTS-ZN NSs (P1-P5) were willing according to liquid–liquid phase break-up method to belittle the use of solvents. The study indicated that apoptosis in MCF-7 containers was confirmed and augmented through caspases reliant signaling pathways and restriction of CDK1 activity due to use of ZN-NSs in transmittal of PTS in comparison accompanying free PTS. Promising research outcomes included extreme EE% nanocomposites, 36 h extended PTS diffusion, a synergized cytotoxicity description, enhanced MCF-7 containers uptake, ameliorated apoptosis induced potential, reinforced mRNA expression of CASP3, CASP7 and CDK1 genes and important oxidative stress.

Author(s) Details:

Majid Mohammad Al-Sawahli,
Faculty of Pharmacy, Ahram Canadian University, 6th October City, Egypt, Department of Pharmaceutics, College of Pharmacy, The Islamic University, Najaf, Iraq and Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafr Elsheikh University, Kafr Elsheikh, Egypt.

Mohamed A. Zarka,
Department of Pharmacognosy, College of Pharmacy, The Islamic University, Najaf, Iraq.

Mowafaq Mohammed Ghareeb,
Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

Hussam Ibrahim Kutbi,
Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Ahmed Kamal Kammoun,
Faculty of Pharmacy, Ahram Canadian University, 6th October City, Egypt, Department of Pharmaceutics, College of Pharmacy, The Islamic University, Najaf, Iraq and Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafr Elsheikh University, Kafr Elsheikh, Egypt.

Ayman M. Noreddin,
Department of Pharmacy Practice, Faculty of Pharmacy, Ahram Canadian University, 6th October City, Egypt and Department of Internal Medicine, School of Medicine, University of California, Irvine, California, USA.

Dalia Farag A. El-Telbany,
Department of Pharmaceutics, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.

Please see the link here: https://stm.bookpi.org/PRAMR-V12/article/view/9662

Bio Based Paper Coatings Containing Protein, Polysaccharide and Essential Oil | Chapter 8 | Current Perspectives on Chemical Sciences Vol. 8

 Surface modifications to packaging paper play an important role in a variety of industries, especially the food industry. In general, packaging paper can be subjected to a wide range of external environmental factors, including humidity, temperature, stress, forces, strain, and chemical reactions, among others. As a result, changes to the paper surface are significant in a number of industries. Because of its porous structure, unmodified paper has low water and oil resistance. Packaging paper was coated successfully with six different coating solutions containing chitosan, zein, and rosemary essential oil in the sample. The chitosan and zein were coated in two layers: one layer of mixed chitosan-rosemary oil and one layer of mixed zein-rosemary oil on the paper. The papers coated with mixed zein-rosemary oil coating solution had improved oil barrier properties, while the papers coated with chitosan-rosemary oil coating solution had decreased water permeability. The water (Cobb60 value of 2.18 g/m2) and oil barrier properties of this two-layer coating were excellent. All coated papers demonstrated excellent thermal stability, especially those that were layer-by-layer coated with chitosan, zein, and rosemary oil. The surface differences of the coated papers, such as closed structure, pores, and smoother surface, were verified using scanning electron microscopy, particularly in layer-wise coated samples. Coated papers with rosemary oil can be used in a variety of applications, including repellents, due to their excellent mechanical and chemical properties. The impact of the investigated dual coating on insect infestation will be investigated in the future.

Author (s) Details

Urška Vrabič Brodnjak
Department of Textiles, Faculty of Natural Sciences and Engineering, University of Ljubljana, Graphic Arts and Design, Snežniška 5, 1000 Ljubljana, Slovenia.

View Book :- https://stm.bookpi.org/CPCS-V8/issue/view/43