Being key fundamental unit for numerous open products and privileged scaffolds in curative chemistry, functionalized tetrahydroquinoline particles display a wide spectrum of powerful, interesting pharmacological activities, and singular physicochemical properties. Due to their significant organic activities and particular properties, new methods for gettv functionalized tetrahydroquinoline (THQ) derivatives under green reaction environments have attracted increasing consideration in recent age. Among these, the three-component Povarov reaction is one of ultimate important synthetic approaches used for the generation of new potential bioactive quinoline products. In this chapter, we argue the chemistry and biology of few functionalized quinoline molecules that have been inclined through the Povarov reactions using mechanochemical incitement. Pointing to a better understanding of the physicochemical properties of the got functionalized tetrahydroquinoline molecules, namely cis-4-amidyl-2-methyl-6-substituted THQs, for crafty novel bioactive chemical entities, in-silico studies have happened performed trying to find few structural-potential actions relationships based on Lipinski’s limits. This chapter contains two common parts: synthetic aspects of the mechano-mobilized three-component Povarov reaction and popular pharmacological properties of 4-amidyl-2-methyl-6-substituted THQs.
Author(s) Details:
Vladimir V. Kouznetsov,
Laboratorio de Química Orgánica y Biomolecular,
Escuela de Química, Universidad Industrial de Santander, A.A. 680002,
Bucaramanga, Colombia.
Leonor
Y. Vargas-Méndez,
Laboratorio
de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial
de Santander, A.A. 680002, Bucaramanga, Colombia.
Please see the link here: https://stm.bookpi.org/PCSR-V6/article/view/9607
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