Alterations in Marker Enzymes and Kidney Function Indices in Datura Metel Aqueous Seed Extract Treated Albino Rats| Chapter 10 | Perspective of Recent Advances in Medical Research Vol. 8

 Datura metel owned by the offspring Solanaceae. It is individual of ultimate abused plant everywhere the planet. This study proposed at determining the effect of Datura metel liquid source extract in light rats. The tombstone enzymes were analyzed utilizing standard order, while sort function indications were persistent utilizing colorimetric form. Phytochemical reasoning revealed the occupancy of miscellaneous phytochemicals. The result of the study told a important declined (P<0.05) in physique weight by any means doses when distinguished accompanying the control. The result still told a important raised (P<0.05) ALP endeavor at all the doses in two together antitoxin and sort. Similarly, ALT and AST venture considerably raised (P<0.05) in two together serum and sort at 200 and 300mg/kg when distinguished accompanying control. Furthermore, the study disclosed a important raised (P<0.05) in antitoxin urea, uric acid and calcium by any means doses of the extract treated groups. However, antitoxin creatinine and potassium levels considerably raised (P<0.05) only at 300mg/kg, when in fact no important various at 100 and 200mg/kg when distinguished accompanying the control. Similarly, the result revealed meaningful raised (P<0.05) antitoxin sodium at 200 and 300mg/kg, and no meaningful distinctness (P>0.05) at 100mg/kg when distinguished accompanying the control. Moreover, serum phosphate level considerably raised (P<0.05) at 200 and 300mg/kg and considerably diminished (P<0.05) only at 100mg/kg of the extract considered groups when distinguished accompanying the control. In contrast, chloride level considerably (P<0.05) decreased by any means doses when distinguished accompanying the control group. The result of the study desires that the liquid beginning extract of Datura metel sources extract may have few nephrotoxic effect on the elementary functions of sort examined in Wister light rats as disclosed in the alterations of the kind functions parameters analysed.

Author(s) Details:

Isah Musa Fakai,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Lukman Ango,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Abubakar Abdulhamid,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Ibrahim Sani,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Angela Nnenna Ukwuani-Kwaja,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Moussa Yahaya,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Fatima Bello,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Jude Nwaogu,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Amina Sulaiman,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Ibrahim Hamza Kankia,
Department of Biochemistry, Umaru Musa ‘Yar’adua University, P.M.B. 2218, Katsina, Katsina State, Nigeria.

Mukhtar Muhammad Warrah,
College of Science, Federal University of Agriculture, P.M.B. 28, Zuru, Kebbi State, Nigeria.

Sufiyanu Abubakar Jiga,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Naima Musa Sani,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Yakubu Musa Yanah,
Department of Biochemistry, Kebbi State University of Science and Technology, P.M.B. 1144, Aliero, Kebbi State, Nigeria.

Amina Musa Sama,
Department of Biology, School of Sciences, Adamu Augie College of Education, P.M.B.1012, Argungu, Kebbi State. Nigeria.

Please see the link here: https://stm.bookpi.org/PRAMR-V8/article/view/9417

Estimation of Urinary Uranium and Urinary 8-OHdG Compound as Biomarker for Oxidative DNA Damage in Exposures and Non-Exposures Adult Healthy Groups in Najaf Governorate| Chapter 9 | Perspective of Recent Advances in Medical Research Vol. 8

 Environmental pollution accompanying many synthetic and material determinants influence people energy everywhere the realm. Najaf governorate of Iraq have organic and human fashioned soures of fallout. Increased number of malignancy cases, autoimmune ailment has happened written in the last few decades. The present study aims to evalute urinary uranium concentration and urinary aggregation of 8-OHdG compound as biomarker for oxidative DNA damage. In this study, a total of 88 athletic persons in Al-Najaf governorate were gathered as environmentally uranium uncoverings n=29 (G1), occupationally uncoverings n=27 (G2), and non-uranium uncoverings n=32 (G3). All groups were subject for guess of urinary uranium aggregation using CR-39 SSNTD arrangement, urinary 8-OHdG compound as a biomarker for oxidative DNA damage was supposed again utilizing Elisa method. Results presented that mean advantage of uranium aggregation were (1.836±0.426 µg/L), (2.02±0.404 µg/L) and (1.755± 0.437 µg/L) for group1, group2 and group3 individually, while the mean principles for 8-OHdG compound were (49.810±15.484 ng/ml), (47.717±14.232 ng/ml) and (46.769±14.249 ng/ml) for the three groups respectively. No meaningful mathematical dissimilarities were written betwixt all dossier got. The results submitted closeness of uranium contamination in all athletic groups containing non-uncovering (G3) as distinguished accompanying citation profit of (WHO, 2004). DNA damage erect further entirely groups according to 8-OHdG levels written. DNA oxidative damage can come from of uranium dirtiness written comprehensively healthful groups of Najaf governorate proven in the study.

Author(s) Details:

Dhuha S. Saleh,
Department of Biology, College of Science, University of Baghdad, Iraq.

Samia K. Abbas,
General Directorate of Education in Najaf Governorate, Iraqi Ministry of Education, Al-Aseel Central Preparatory for Girls, Iraq.

Hayder S. Hussain,
Department of Physics, College of Science, University of Baghdad, Iraq.

Please see the link here: https://stm.bookpi.org/PRAMR-V8/article/view/9417