The purpose of this chapter is to demonstrate how size correlation analysis can be used to forecast the size of polymeric solution droplets starting from process variables and material characteristics. The droplets are created using ultrasonic-assisted atomization, a mechanical technique for dispersing liquid into thin spray. These latter ones are created for the aim of microencapsulation, which is useful in the creation of medications. When compared to other atomization methods, the advantages of ultrasonic atomization include lower energy requirements, smaller apparatuses, lower levels of mechanical stress in materials, and others. traditional methods. An overview of spraying techniques and the fundamentals of atomization are provided for this purpose. This work specifically discusses the function of important parameters in atomization helped by ultrasonics and presents correlations to forecast droplet size. Alginate solution sprays are intentionally created and subjected to experimental (measurements) and theoretical (calculation) size observations due to the interest in microencapsulation for medicinal applications. Because the size of microdroplets plays such a crucial role in pharmaceutical manufacture and because the size of drug carriers can affect the rate and duration of release of encapsulated therapeutic agents, the ability to apply trustworthy empirical correlations is very helpful.
Anna Angela Barba
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano SA, Italy and Enhanced Systems and Technologies, EST Srl, University Spin-Off, , Via Circumvallazione n.39, 83100 Avellino, Italy and Eng4Life Srl, University Spin-Off, , Via Circumvallazione n.39, 83100, Avellino, Italy.
Matteo d’Amore
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano SA, Italy and Eng4Life Srl, University Spin-Off, , Via Circumvallazione n.39, 83100, Avellino, Italy.
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