A lifelong sensitivity to the gliadin present in the gluten proteins found in wheat, barley, rye, and other cereals is known as celiac disease (CD). Although there is some hereditary predisposition in the patient's ancestors, celiac disease is not a disease that is transmitted by Mendelian genetics. Gluten intolerance results in severe intestinal mucosal damage, including villous atrophy. The body responds to the intolerance to gluten by producing antibodies, which in turn harm the intestinal mucosa and reduce intestinal absorption. On chromosome 2, 39 genomic areas have recently been linked to CD. The genes in these regions are geographically adjacent to the HOXD locus found on chromosome 2q31. The 39 transcription factors known as Class I homeobox genes (HOX in humans) interact with non-coding RNA to regulate embryonic development and the cell memory programme. Does the HOX gene network have the ability to govern the modification of the cell memory programme in the CD since I see the HOX network as "The Rosetta Stone" of human biology?
Procino Alfredo,
Department of Neurosciences, Reproductive and Odontostomatologic Sciences, Medical School Federico II, Naples, Italy.
Please see the link here: https://stm.bookpi.org/ETDHR-V9/article/view/7451
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