Background: Alternative or supplementary medications are urgently required due to the worrisome issue of drug-resistant Mycobacterium tuberculosis (M.tb). Repurposing already available, FDA-approved medications might help achieve this. In this work, drug-resistant M. tb isolates were used to assess the anti-tuberculosis efficacy of microbial siderophores. On mammalian cell lines, the siderophores' cytotoxicity toward cells was also assessed.
Methods: Mycobacteria Growth Indicator Tube drug susceptibility testing was
used to evaluate the anti-tubercular activity of the siderophores. The MTT test
was used to assess the siderophores' cytotoxic effects on mammalian cells.
Results: The siderophores tested were shown to be efficient both on their own
and when combined with main or secondary anti-TB medications that are often
recommended but ineffective against drug-resistant M.tb isolates. Interestingly,
When siderophore MIC was evaluated in conjunction with anti-tubercle
medications, it fell. There was no discernible cell cytotoxicity seen.
Siderophores are safe supplements to the anti-TB treatment regimen that may be
helpful in overcoming drug-resistant tuberculosis.
Author (s) Details:
Karuna Gokarn,
Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Mumbai, 400- 002, India and Department of Microbiology, St. Xavier’s College, Mumbai, India.
Ramprasad Balikaran Pal,
Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Mumbai, 400- 002, India.
Please see the link here: https://stm.bookpi.org/ETDHR-V9/article/view/7452
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