An autoimmune disease with an unknown cause and poor treatment outcomes, multiple sclerosis (MS) has a high societal cost. It only makes sense that we look into the various factors (genetic, hormonal, and environmental) that play a role in the autoimmune process in order to better control the immune system's dysregulation given that the myelin destruction model, clinical manifestations, and therapeutic response potential in MS are all linked. Results from epidemiological and clinical investigations strongly imply that variations in vitamin D blood concentrations are connected to the degree of MS risk, the phases of remission and relapse, and gender differences in vitamin D metabolism. To achieve proper calcium metabolism, the blood vitamin D concentration should range from 50 to 80 nmol/l. The application of vitamin D in an ideally effective and safe dosage, a subset of MS patients who are suitable for vitamin D treatment, and the optimal vitamin D blood concentration necessary to regulate the aberrant immune response in MS patients are all discussed. Despite the fact that 17 years is a very short period of time to infer that the population's gene pool has altered, the MS prevalence rate in Bulgaria has doubled in that time. More investigation into potential connections between diverse environmental elements and their role in the development of illnesses is therefore both appropriate and necessary.
Georgi S. Slavov,
Department of Neurology, Medical University, Plovdiv, Bulgaria.
Please see the link here: https://stm.bookpi.org/CODHR-V1/article/view/7435
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