The current study's objectives are to compare the minimum inhibitory concentrations (MICs) of vancomycin, teicoplanin, linezolid, and erythromycin for methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) and MRSA, respectively. A nine-month prospective research was carried out. Staphylococcus aureus strains with clinical associations that were found in patients who were hospitalised were included in the research. The MIC of erythromycin, vancomycin, teicoplanin, and linezolid was determined using the E-test (HIMEDIA). Risk factors such immunosuppression, prior hospitalisation, surgical technique utilised, invasive equipment, and antibiotic treatment were evaluated using a pre-set methodology. 62 S. aureus strains in all were included in the investigation. 40% of the S. aureus strains tested positive for antibiotic resistance. Risk factors, intrusive technology, prior hospitalisation, and coexisting diseases have all been demonstrated to be strongly associated with MRSA. Antimicrobial treatment and immunosuppression were discovered to have a slenderly significant association. In 56% of instances, MRSA exhibited erythromycin resistance, while MSSA exhibited none. When compared to vancomycin and linezolid, teicoplanin was found to have the lowest in vitro MIC50 and mean values against MRSA and MSSA. In terms of clinical and microbiological cure, teicoplanin has not been proven to be more successful than vancomycin, but it has a superior toxicity profile and a reduced risk of adverse effects. MRSA infection management may benefit from reducing risk factors and putting an emphasis on alternative medications and infection control techniques.
Sonal Gupta,
Govind Ballabh Pant Institute of Medical Research and Education (GIPMER), Delhi, India.
Bibhabati Mishra,
Department of Microbiology, Govind Ballabh Pant Institute of Medical Research and Education (GIPMER), Delhi, India.
Archana Thakur,
Department of Microbiology, Govind Ballabh Pant Institute of Medical Research and Education (GIPMER), Delhi, India.
Vinita Dogra,
Department of Microbiology, Govind Ballabh Pant Institute of Medical Research and Education (GIPMER), Delhi, India.
Poonam Sood Loomba,
Department of Microbiology, Govind Ballabh Pant Institute of Medical Research and Education (GIPMER), Delhi, India.
Manisha Jain,
Department of Microbiology, Govind Ballabh Pant Institute of Medical Research and Education (GIPMER), Delhi, India.
Aradhana Bhargava,
Department of Microbiology, Govind Ballabh Pant Institute of Medical Research and Education (GIPMER), Delhi, India.
Please see the link here: https://stm.bookpi.org/CODHR-V1/article/view/7424
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