Wound Healing Metabolites as the Right Medicines for the Therapy of Diseases Arising due to the Collapse of Chemo-Surveillance | Chapter 6 | Current Overview on Disease and Health Research Vol. 1

This study's goals were to investigate the mechanics of wound healing and look for wound healing metabolites as potential treatments for illnesses brought on by the failure of chemo-surveillance, the majority of which were incurable. Cancer evolution and wound healing have many similarities, and progenitor stem cells (PSCs) play a significant role in both processes. Wound healing requires PSC proliferation and terminal differentiation (TD). Wounds cause biological and immunological reactions. In order to create ProstaGlandins (PGs), which are active Differentiation Inducers, Arachidonic Acid (AA) is released from membrane-bound phosphatidylinositol as part of the biological response (DIs). The DIs AA and PGs promote wound healing. Tumor Necrosis Factor (TNF), also known as cachectin due to its ability to create the symptom of cachexia, is produced as a result of an immunological reaction. Cachexia is a poor indication of wound healing because TNF can lead to an increase in the excretion of low molecular weight metabolites in the urine, resulting in the loss of metabolites necessary for wound healing. As a result, chemo-functionality surveillance is essential for assessing how well wounds heal. A wound can always heal without leaving a scar if the chemo-surveillance system functions as well in cancer patients as it does in healthy individuals. However, if the effectiveness of chemo-surveillance has been compromised by pathological illnesses that are generating cachexia symptoms, wound healing may be hampered, leaving an unsightly scar. alternatively, in the case of irreversible brain injury, dementia; in the event of Covid-19 infection, tissue fibrosis; or, in the case of malignancy, the most terrifying scenario. In relation to aesthetic surgery and regenerative medicine, ugly scars on the visible surface are a medical problem. Studying wound healing can assist repair wounds without leaving scars and provide a more effective treatment plan for illnesses brought on by the breakdown of chemo-functionality.

Author (s) Details:

Ming C. Liau,
CDA Therapeutics, Inc. 3308 Sky Run Court, Missouri City, TX 77459, USA.

Christine Liau Craig,
CDA Therapeutics, Inc. 3308 Sky Run Court, Missouri City, TX 77459, USA.

Please see the link here: https://stm.bookpi.org/CODHR-V1/article/view/7426