Refining UPLC Methodology for Comprehensive Analysis of Molindone and Its Impurities | Chapter 6 | Recent Developments in Chemistry and Biochemistry Research Vol. 9

Background: Sensitive determination of molindone and its impurities to be developed for the molindone drug substance/products.

Aim: Effective chromatographic separation was achieved on a phenyl-hexyl stationary phase for the determination of molindone and its related impurities.

Methods: The economical and straightforward mobile phase combination delivered in gradient mode at a flow rate of 0.6 mL/min at 254 nm using the phenyl-hexyl column with the dimension of (50 × 2.1 mm, 1.9 µ particles) with the help of an ultra-performance liquid chromatography (UPLC) system.

Results: In the developed method, the resolution between molindone and its related compounds was more significant than 2.0. Regression analysis shows an r₂ value (correlation coefficient square) greater than 0.999 for molindone and its associated compounds. This method could detect related compounds of molindone at a level below 0.009% with respect to a test concentration of 500 µg/mL for a 2.0 µL injection volume.

Conclusion: The method has shown good, consistent recoveries for related compounds (90-110%). The test solution was found to be stable in the diluent for 48 hours. The drug was subjected to stress conditions. The mass balance was found to be close to 99.3%. The validated method may be used for the routine analysis of the determination of related compounds of molindone from the bulk drug, pharmaceutical preparation, and other quality control samples of product development.

 

Author (s) Details

 

Balaji Nagarajan
Apicore LLC, East Windsor, New Jersey, 08520, United States.

 

Gunasekar Manoharan
New Jersey Bioscience Centre, 675 US Highway 1, North Brunswick, New Jersey, 08902, United States.

 

Ganapathy Narayanan Shanmugam
New Jersey Bioscience Centre, 675 US Highway 1, North Brunswick, New Jersey, 08902, United States.

 

Nataraj Palaniyappan
Shri Jagdishprasad Jhabarmal Tibrewala University, Rajasthan, 333001, India.

 

Abhinav Yarragunta
Majoring in Computer Engineering, Florida Semiconductor Institute, University of Florida, United States.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v9/3425

Preventing Adverse Effects of Medicines: A Knowledge Attitude and Practice Study of Leaders in the Nigerian Public Health Supply Chain | Chapter 9 | New Advances in Medicine and Medical Science Vol. 8

 Pharmacovigilance is delineated as ‘‘the science and activities having connection with the detection, estimate, understanding and prevention of adverse belongings or any additional drug-related problem.” This study checked the knowledge, stance, and practice of pharmacovigilance by leaders in the public health drug supply chain management in Nigeria. The key practice approach of pharmacovigilance includes spontaneous reporting of antagonistic drug reactions and guaranteeing continuous post-marketing following of the quality and security of medicines. The success of pharmacovigilance depends on the knowledge, attitude, and willing participation of healthcare personnel, sufferers, and institutions. A cross-divided approach was used in the survey of 209 leaders of picked public health organisations. Purposive examining technique was used to administer certified semi-organized questionnaire. Questions were drawn from the Nigerian social pharmacovigilance policy. A 55% answer  rate was received as feedback. Among the responders, healing doctors and medical workshop scientists had better knowledge and practice of pharmacovigilance than pharmacists. Factors guide practice of pharmacovigilance include knowledge of the pharmacovigilance policy (OR = 1.90; P = .11), training given by respondents' organisations (OR = 1.34; P = .48), accused' organisation receiving periodic revises from the National Pharmacovigilance Centre (OR = 1.11; P = .85) and respondents alone receiving periodic revises (OR = .83; P = .73). In conclusion, the study suggests that listening the safety and quality of cures in the public health scope of Nigeria could improve through raised awareness of the interstate pharmacovigilance policy, training in pharmacovigilance, and regular safety media by the national pharmacovigilance centre.

Author(s) Details:

Anthony Obieze,
USAID Global Health Supply Chain-Procurement and Supply Management Project, Abuja, Nigeria.

Please see the link here: https://stm.bookpi.org/NAMMS-V8/article/view/11077

Size Correlations Analysis of Polymeric Solution Microdroplets by Ultrasonic Atomization | Chapter 3 | Research Developments in Science and Technology Vol. 9

The purpose of this chapter is to demonstrate how size correlation analysis can be used to forecast the size of polymeric solution droplets starting from process variables and material characteristics. The droplets are created using ultrasonic-assisted atomization, a mechanical technique for dispersing liquid into thin spray. These latter ones are created for the aim of microencapsulation, which is useful in the creation of medications. When compared to other atomization methods, the advantages of ultrasonic atomization include lower energy requirements, smaller apparatuses, lower levels of mechanical stress in materials, and others. traditional methods. An overview of spraying techniques and the fundamentals of atomization are provided for this purpose. This work specifically discusses the function of important parameters in atomization helped by ultrasonics and presents correlations to forecast droplet size. Alginate solution sprays are intentionally created and subjected to experimental (measurements) and theoretical (calculation) size observations due to the interest in microencapsulation for medicinal applications. Because the size of microdroplets plays such a crucial role in pharmaceutical manufacture and because the size of drug carriers can affect the rate and duration of release of encapsulated therapeutic agents, the ability to apply trustworthy empirical correlations is very helpful.

Author (s) Details

Anna Angela Barba
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano SA, Italy and  Enhanced Systems and Technologies, EST Srl, University Spin-Off, , Via Circumvallazione n.39, 83100 Avellino, Italy and  Eng4Life Srl, University Spin-Off, , Via Circumvallazione n.39, 83100, Avellino, Italy.

Matteo d’Amore
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano SA,  Italy and Eng4Life Srl, University Spin-Off, , Via Circumvallazione n.39, 83100, Avellino, Italy.

View Book :- https://stm.bookpi.org/RDST-V9/article/view/7548

Study on the Diversity in Sesame| Chapter 1 | Current Topics in Agricultural Sciences Vol. 7

In addition to being a popular food, sesame is utilised in pharmaceutics, manufacturing, and as a biofuel. Sesame has been propagated and grown in many ecological regions, including India, for hundreds of years. Sesame's ancient roots were boosted by its ability to grow where other crops couldn't. It's also the sort of crop that thrives in droughts, hot weather, and soil moisture left over after the monsoons have passed, or even when rains fail. Sesame productivity in India is not consistent. Although the maximum production was attained in 2003, productivity has fluctuated over time.

Author(s) Details:

Adil Iqbal,
Department of Genetics and Plant Breeding, Institute of Agricultural Science, University of Calcutta, Kolkata, India and AICRP on Sesame and Niger (ICAR), Kolkata Centre, India.

Rambilash Mallick,
AICRP on Sesame and Niger (ICAR), Kolkata Centre, India and Department of Agronomy, Institute of Agricultural Science,  University of Calcutta, Kolkata, India.

Sabyasachi Kundagrami,
Department of Genetics and Plant Breeding, Institute of Agricultural Science, University of Calcutta, Kolkata, India and AICRP on Sesame and Niger (ICAR), Kolkata Centre, India.

Please see the link here: https://stm.bookpi.org/CTAS-V7/article/view/6777

Study about Nano Polyphenol: Biomaterial in Functional Food and Its Preparation | Chapter 11 | Current Aspects in Pharmaceutical Research and Development Vol. 4

 Polyphenols, which comprise lignin, flavonoids, polyphenols, phenolic acid, and stilbenes, are found in all plants and some animals and have a wide range of structures and bioactivities. They are valued for their antioxidant, anti-cardiovascular, and human applications, although polyphenol use for babies and pregnant women still raises many problems, while nano polyphenols have recently gained a lot of attention. As a result, the chapter concentrated on polyphenols (definition, categorization, structure, and resources), their activity and mechanisms (antioxidant and anti-cardiovascular), their usage in babies and pregnant women, and nano polyphenol manufacturing methods (ten extraction methods of polyphenols and eleven methods of nano polyphenol preparations). Nanopolyphenols are essential for future functional foods and pharmaceuticals, as well as human disease and ageing prevention, but their usage is restricted to pregnant women and children under the age of 18.

Author(S) Details

Pham Thanh Thuan
Department of General Surgery, Ninh Thuan Province General Hospital, Ninh Thuan 590000, Vietnam.

Pham Van Thinh
Ho Chi Minh University of Food Industry, Ho Chi Minh 700000, Vietnam.

Pham Thi Thanh Thao
Department of Obstetrics, Hung Vuong hospital, Ho Chi Minh 700000, Vietnam.

Truong Ngoc Minh
Vietnam Academy of Science and Technology (VAST), Center for Research and Technology Transfer, 18 Hoang Quoc Viet Road, 100000 Hanoi, Vietnam. and Vietnam Academy of Science and Technology (VAST), Institute of Applied Mechanics and Informatics, Hanoi 100000, Vietnam.

View Book:- https://stm.bookpi.org/CAPRD-V4/article/view/4711