This study sought to define the potential roles of immunologic memory and molecular mimicry as pathways that may connect SARS-CoV-2 infection and vaccination with cardiovascular disorders (CVDs).
It was looked at if human proteins that are impacted by CVDs have pentapeptide
immune determinants with the SARS-CoV-2 spike glycoprotein (gp).
The majority of the shared peptides are found in infectious pathogens to which
the human population has generally been exposed, and comparative sequence
analyses show that SARS-CoV-2 spike gp and human proteins related to CVDs share
a high level of peptide sharing. The shared peptides have immunological
potential because they are also a part of experimentally validated SARS-CoV-2
spike gp-derived epitopes.
Cross-reactivity and peptide sharing most likely represent, respectively, the
molecular foundation and fundamental mechanism connecting SARS-CoV-2 exposure
and CVDs, with the individual's prior infection history playing a key role in
defining and defining the immune response as well as the pathologic autoimmune
sequelae.
Author(s) Details:
Department of Biosciences, Biotechnologies and Biopharmaceutics, University
of Bari, Italy.
Please see the link here: https://stm.bookpi.org/CPMS-V4/article/view/7367
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