Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Cardiac Titin Protein: A Potential Cause of Sudden Unexpected Deaths | Chapter 5 | Research Developments in Medicine and Medical Science Vol. 6

 This study documents that 17 pentapeptides are coarse to Respiratory Syncytial Virus (RSV) F antigen and Titin, a human cardiac protein whose alterations are connected to sudden surprising death (SUD) condition. The peptide sharing has a relevant invulnerable-pathological potential because many of the common sequences are again present in immunopositive RSV F-derived epitopes, so making likely the possibility that antagonistic-Titin autoimmune cross-reactivity and resultant SUDs can be started by vaccines based on the RSV F antigen.

Author(s) Details:

Darja Kanduc,
Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Italy.

Please see the link here: https://stm.bookpi.org/RDMMS-V6/article/view/10021

Influenza, SARS-CoV-2, Titin, and Sudden Unexpected Deaths: On the Risk of Multiple Vaccinations| Chapter 1 | Current Innovations in Medicine and Medical Science Vol. 10

 Objective concerning this short review is to recall data that link Influenza virus, harsh acute respiratory disease-coronavirus-2 (SARS-CoV-2), and the human cardiac Titin protein to sudden unexpected dying (SUDs) through molecular mime. Indeed, a direct causality between Influenza bacterium and SUDs has been again and again reported in clinical article and, more recently, also SARS-CoV-2 immunization has been had connection with an alarming incidence of SUDs. Hence, it is of pertinence to highlight that Influenza virus and SARS-CoV-2 antigens, that is, hemagglutinin and spike glycoprotein (gp), share invulnerable determinants with the SUD-connected Titin. Such a peptide sharing and the consequent autoimmune cross-sensitivity are even more significant because might enable an aggressive implementation of SUD occurrences following simultaneous multiple antagonistic-influenza and anti-SARS-CoV-2 vaccinations. On the whole, this chance imposes caution and careful immunization clinical trials.

Author(s) Details:

Darja Kanduc,
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari-70126, Italy.

Please see the link here: https://stm.bookpi.org/CIMMS-V10/article/view/8861

From SARS-CoV-2 to Myocarditis and Sudden Death via Molecular Mimicry and Immunologic Memory | Chapter 12 | Current Practice in Medical Science Vol. 4

This study sought to define the potential roles of immunologic memory and molecular mimicry as pathways that may connect SARS-CoV-2 infection and vaccination with cardiovascular disorders (CVDs).

It was looked at if human proteins that are impacted by CVDs have pentapeptide immune determinants with the SARS-CoV-2 spike glycoprotein (gp).

The majority of the shared peptides are found in infectious pathogens to which the human population has generally been exposed, and comparative sequence analyses show that SARS-CoV-2 spike gp and human proteins related to CVDs share a high level of peptide sharing. The shared peptides have immunological potential because they are also a part of experimentally validated SARS-CoV-2 spike gp-derived epitopes.

Cross-reactivity and peptide sharing most likely represent, respectively, the molecular foundation and fundamental mechanism connecting SARS-CoV-2 exposure and CVDs, with the individual's prior infection history playing a key role in defining and defining the immune response as well as the pathologic autoimmune sequelae.

Author(s) Details:

Darja Kanduc,

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy.

Please see the link here: https://stm.bookpi.org/CPMS-V4/article/view/7367