Prevalence of Intermittent Allergic Rhinitis to Pollen among Students of the Polydisciplinary Faculty of Beni Mellal, Morocco| Chapter 7 | An Overview of Disease and Health Research Vol. 3

Background: The frequency of respiratory allergy, including asthma and allergic rhinitis due to pollen, is increasing in the young and urban dwellers in developed countries. Allergic rhinitis negatively affects academic performance and quality of life. A better understanding of the prevalence and characteristics of allergy can help guide to strategy of management against the development of allergic rhinitis, asthma and anaphylaxis within and outside academic institutions in order to reduce the risk of morbidity and mortality.

 

Objective: This study was carried out to characterise pollen allergy and its relation with the environment at a university institution in order to propose a strategy of management against this disease.

 

Methods: The study was conducted at the Polydiscipline Faculty of Beni Mellal. For this study, 529 students (female 316 and male 213) were selected randomly from a set of about 7000 students from the institution. To support the descriptive analysis, a survey was administered to collect relevant data.

 

Results: The percentage of students allergic to pollen surveyed in the FPBM was 39%. This percentage was within the confidence interval of all students in the allergic FPBM [35%; 44%], estimated 5% error risk. The results proved that the selected sample was representative. The most common symptoms of pollen allergy among the students were the nasal symptoms (sneezing and nasal itching). These symptoms characterise allergic rhinitis. This study also revealed that the olive tree was the main allergen causing pollen allergy in the region. Moreover, most students experienced allergic reactions during the spring season; this could be explained by the pollination of the olive tree in this period. The majority of surveyed students were allergic to one or two types of plants, and the cross-reactivity between pollen and food was the most dominant.

 

Conclusion: This study is particularly significant, as no prior studies have documented a high prevalence of pollen allergy in the Beni Mellal-Khenifra region. The olive tree was the main allergen; this can be explained by the richness of the region of Beni-Mellal-Khénifra with this plant. These results are unexpected; normally, these youngsters must present a resistance to the pollen present in the region because they are native and have an adaptation to the environment. However, nearly a quarter of the young people surveyed in the area present an allergy. These findings highlight the need for further investigation into environmental factors and their role in the growing prevalence of pollen allergies.

 

Author(s) Details

 

SABOUR ALAOUI Sanaa
Polyvalent Research and Development Team Polydisciplinary Faculty, Sultan Moulay Sliman University of Beni Mellal, Morocco.

 

Please see the book here:- https://doi.org/10.9734/bpi/aodhr/v3/5696

 

Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Cardiac Titin Protein: A Potential Cause of Sudden Unexpected Deaths | Chapter 5 | Research Developments in Medicine and Medical Science Vol. 6

 This study documents that 17 pentapeptides are coarse to Respiratory Syncytial Virus (RSV) F antigen and Titin, a human cardiac protein whose alterations are connected to sudden surprising death (SUD) condition. The peptide sharing has a relevant invulnerable-pathological potential because many of the common sequences are again present in immunopositive RSV F-derived epitopes, so making likely the possibility that antagonistic-Titin autoimmune cross-reactivity and resultant SUDs can be started by vaccines based on the RSV F antigen.

Author(s) Details:

Darja Kanduc,
Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Italy.

Please see the link here: https://stm.bookpi.org/RDMMS-V6/article/view/10021

Influenza, SARS-CoV-2, Titin, and Sudden Unexpected Deaths: On the Risk of Multiple Vaccinations| Chapter 1 | Current Innovations in Medicine and Medical Science Vol. 10

 Objective concerning this short review is to recall data that link Influenza virus, harsh acute respiratory disease-coronavirus-2 (SARS-CoV-2), and the human cardiac Titin protein to sudden unexpected dying (SUDs) through molecular mime. Indeed, a direct causality between Influenza bacterium and SUDs has been again and again reported in clinical article and, more recently, also SARS-CoV-2 immunization has been had connection with an alarming incidence of SUDs. Hence, it is of pertinence to highlight that Influenza virus and SARS-CoV-2 antigens, that is, hemagglutinin and spike glycoprotein (gp), share invulnerable determinants with the SUD-connected Titin. Such a peptide sharing and the consequent autoimmune cross-sensitivity are even more significant because might enable an aggressive implementation of SUD occurrences following simultaneous multiple antagonistic-influenza and anti-SARS-CoV-2 vaccinations. On the whole, this chance imposes caution and careful immunization clinical trials.

Author(s) Details:

Darja Kanduc,
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari-70126, Italy.

Please see the link here: https://stm.bookpi.org/CIMMS-V10/article/view/8861

The Role of Molecular Mimicry and Autoimmunity in the SARS-CoV-2-Induced Diseases: An a Posteriori Analysis | Chapter 8 | Current Innovations in Medicine and Medical Science Vol. 4

 SARS-CoV-2-derived epitopes were examined for peptide sharing with human proteins in 2020, during the time of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, in order to determine the likelihood that the coronavirus exposure would cause autoimmune cross-reactivity. It was discovered that the immunoreactive epitopes found in SARS-CoV-2 are generally made up of peptide sequences found in human proteins as well. These sequences, when altered, are linked to a variety of diseases, from respiratory distress to multi-organ failure. It is noteworthy that the peptide sharing also included antigens relevant to fetal/infantile illnesses and tumour suppressor proteins. According to scientific evidence, passive or active SARS-CoV-2 infection can lead to autoimmunity due to molecular mimicry and the resulting cross-reactivity. In order to prevent autoimmune reactions, the clinical data suggested vaccine composition based on unique viral peptide sequences. The large wave of severe adverse effects expected in 2020 and already occurring after the widespread administration of the anti-SARS-CoV-2 vaccine based on conventional vaccine formulations are now, in 2022, explained by the data.

Author(s) Details:

Darja Kanduc,
Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Italy.

Please see the link here: https://stm.bookpi.org/CIMMS-V4/article/view/8398

From SARS-CoV-2 to Myocarditis and Sudden Death via Molecular Mimicry and Immunologic Memory | Chapter 12 | Current Practice in Medical Science Vol. 4

This study sought to define the potential roles of immunologic memory and molecular mimicry as pathways that may connect SARS-CoV-2 infection and vaccination with cardiovascular disorders (CVDs).

It was looked at if human proteins that are impacted by CVDs have pentapeptide immune determinants with the SARS-CoV-2 spike glycoprotein (gp).

The majority of the shared peptides are found in infectious pathogens to which the human population has generally been exposed, and comparative sequence analyses show that SARS-CoV-2 spike gp and human proteins related to CVDs share a high level of peptide sharing. The shared peptides have immunological potential because they are also a part of experimentally validated SARS-CoV-2 spike gp-derived epitopes.

Cross-reactivity and peptide sharing most likely represent, respectively, the molecular foundation and fundamental mechanism connecting SARS-CoV-2 exposure and CVDs, with the individual's prior infection history playing a key role in defining and defining the immune response as well as the pathologic autoimmune sequelae.

Author(s) Details:

Darja Kanduc,

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy.

Please see the link here: https://stm.bookpi.org/CPMS-V4/article/view/7367

An Introduction to Seafood Allergy: With Special Mention on Shellfish Allergens | Chapter 09 | Emerging Trends in Disease and Health Research Vol. 2

 Seafood is a staple of most people's diets around the world. More frequent reports of adverse responses have come from increased production and consumption, stressing the need for more specific diagnosis and treatment of seafood allergy. The primary allergen in shellfish has been identified as tropomyosin, which induces IgE-mediated hypersensitivity. Oral allergy syndromes, urticaria, and anaphylaxis are among the symptoms. Shellfish have a lot of cross-reactivity. Clinical cross-reactivity with other species, as well as possible new therapy techniques, require further research. This chapter's information on diagnosis, treatment, and regulation can help you prevent developing a seafood allergy.

Author(S) Details

D. M. Affarin Tinku
Department of Post-Harvest Technology, ICAR-Central Institute of Fisheries Education, Versova, Mumbai-400061, Maharashtra, India.

P. Layana
Department of Post-Harvest Technology, ICAR-Central Institute of Fisheries Education, Versova, Mumbai-400061, Maharashtra, India.

Amjad K. Balange
Department of Post-Harvest Technology, ICAR-Central Institute of Fisheries Education, Versova, Mumbai-400061, Maharashtra, India.

View Book:- https://stm.bookpi.org/ETDHR-V2/article/view/5572