The goal of this study was to develop an oral pulsatile drug delivery system based on a chronopharmaceutical strategy for the treatment of hypertension that would allow felodipine to be released at a certain time. By using the press coating approach, the system was created in the shape of two stacked tablets. Physical combinations of felodipine with innovative micro encapsulated solubilizers like Sepitrap 4000, Sepitrap 80 produced by direct compression process make up the active fast release core tablet. According to dissolution trials, core tablets containing these novel surfactants released the entire amount in 15 and 30 minutes, respectively. The decrease in crystallinity of felodipine, as determined by XRD data, was attributable to the enhanced dissolution and rapid release. Different grades of hydroxy propyl methyl cellulose (HPMC) E5, E15, and E50 were used to dry coat the optimised RRCT. Based on the in-vitro release profile, it was discovered that the improved formulation F6 had a 7.5-hour lag time, which was consistent with the chronotherapeutic goal of hypertension. The drug's crystallinity was reduced, with no interaction between the drug and the excipients, according to solid state characterization (FTIR, XRD tests).
Author(s) Details:
Rajeshri Dhurke,
Department of Pharmaceutics at St. Peter’s Institute of Pharmaceutical
Sciences, Warangal, Telangana, India.
Domala Ramyasree,
Department of Pharmaceutics at St. Peter’s Institute of Pharmaceutical
Sciences, Warangal, Telangana, India.
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