Chronotherapy and Pulsatile Drug Delivery Systems: Aligning Pharmacotherapy with Circadian Rhythms |Chapter 3 | Pharmaceutical Science: New Insights and Developments Vol. 10

 

Chronotherapy is a therapeutic strategy that synchronises the timing of drug administration with the body’s endogenous circadian rhythms to enhance efficacy and reduce adverse effects. These rhythms regulate physiological processes such as hormone secretion, metabolism, sleep–wake cycles, and cardiovascular function, making timing an essential component of optimised therapy. Pulsatile drug delivery systems complement chronotherapy by releasing drugs in a programmed manner after a predetermined lag time, allowing the drug to reach peak concentrations at the time when symptoms are most severe or when the body is most receptive to treatment. Chronotherapy can be implemented using various approaches, including delayed or advanced sleep phase therapy, rest-phase adjustment, and combination interventions involving light or behavioural therapy. In clinical practice, chronotherapy has shown particular benefit in arthritis management—night-time dosing of NSAIDs or corticosteroids helps reduce early-morning stiffness in rheumatoid arthritis, while morning dosing of COX-2 inhibitors is more effective for osteoarthritis. Overall, aligning drug delivery with circadian patterns offers a promising strategy to enhance therapeutic outcomes in time-dependent diseases.

 

 

Author(s) Details

Y. Ismail
Crescent School of Pharmacy, B. S. Abdur Rahman Crescent Institute of Science and Technology, GST Road, Vandalur, Chennai 600048, Tamil Nadu, India.

 

Vijaya Kumar Voleti
School of Pharmacy, Sathyabama Institute of Science and Technology, OMR Road, Chennai, Tamil Nadu, India.

 

S. Priya
School of Pharmacy, Sathyabama Institute of Science and Technology, OMR Road, Chennai, Tamil Nadu, India.

 

Please see the book here :- https://doi.org/10.9734/bpi/psnid/v10/7019

Chronotherapy: Unleashing the Precision of Time for Enhanced Treatment Strategies | Chapter 4 | Pharmaceutical Science: New Insights and Developments Vol. 8

 

Chronotherapy is an emerging discipline in medicine that emphasises aligning drug administration with the body’s inherent biological rhythms, particularly the circadian clock. Recognising that critical physiological functions such as hormone secretion, enzymatic activity, and metabolism fluctuate throughout the day, chronotherapy aims to enhance therapeutic efficacy and reduce adverse effects by synchronising treatment timing with these natural cycles. Recent progress in this field includes the development of time-specific drug formulations and advanced delivery systems, as well as computational tools and algorithms designed to tailor treatment regimens to individual patients. Although still evolving, chronotherapy holds significant promise for optimising clinical outcomes and advancing personalised medicine. The present study focuses on different aspects of Chronotherapy. This study explored the recent advances in chronotherapy, highlighting the potential it holds for revolutionising healthcare. Further research is required to fully understand the intricate mechanisms underlying chronotherapy and to explore its application across various medical conditions.

 

 

Author(s) Details

Subham Kumar Panda
Department of Reproductive and Developmental Toxicology, Vipragen Biosciences Private Limited, 67B, Hootagalli Industrial Area, Mysuru, Karnataka, India.

 

V. G. S. Sharma
Department of Preclinical Toxicology, Vanta Bioscience Limited, SIPCOT Industrial Complex, Gummidipundi, Tamil Nadu, India.

 

B. Ray
Nityananda College of Pharmacy (Unit of B.C.E.T.), Balasore, India.

 

Aditya Kumar Jena
Nityananda College of Pharmacy (Unit of B.C.E.T.), Balasore, India.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v8/6183

Chronotherapeutic Drug Delivery System - A Detailed Study | Chapter 11 | Novel Aspects on Pharmaceutical Research Vol. 8

The study of during the day clocks and the natural platform's likely uses for them has managed to an increased interest in chronotherapy research. This area of research specifies important visions for improving current drug delivery science. Chronotherapy involves executing drugs in sync with circadian music to target particular sites in the body. Among them pulsatile drug transfer system gains recent consideration where the drug be necessary to deliver at desired scene with official time of region by offering multiple benefits for the sufferers. Recently, research has been attracted on chronotherapeutics for the disease such as asthma, arthritis, malignancy, diabetes, hypertension, hypercholesterlemia, congestive heart failure and stroke. They have been concocted according to the biological clock of the body to exhibit  complete release of drug after the particularized lag opportunity, especially for drugs that undergo first pass absorption by liver and drug requirement all the while nocturnal dosing. There have existed various attempts to cultivate a therapeutic system that gives drugs to treat rhythmic diseases established their occurrence. The ideal chronotherapeutic plan should release the drug rapidly and entirely after a distinguishing lag time. Researchers have directed on developing chronotherapeutic drug transfer systems using polymer films that are dependent on something erosion, slippery, or opposing as well as sonic cues systems for giving drugs. This chapter investigate the idea of chronotherapy, problems knowing in its progress, present methods, and potential uses in medication transmittal for treating disorders affiliated to circadian rhythm.

Author(s) Details:

D. Nagasamy Venkatesh,
Department of Pharmaceutics, JSS College of Pharmacy, Rocklands, Post Box No: 20, Ootacamund-643001, Tamil Nadu, India.

N. Arun,
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education & Research, Mysuru-643 001, India.

S. D. Shanmugakumar,
Jyothishmathi Institute of Pharmaceutical Sciences Thimmapur, Karimnagar, Telanagana-505481, India.

Please see the link here: https://stm.bookpi.org/NAPR-V8/article/view/11658

Pulsatile Delivery System for Antihypertensive Drug| Chapter 11 | Current Aspects in Pharmaceutical Research and Development Vol.9

 The goal of this study was to develop an oral pulsatile drug delivery system based on a chronopharmaceutical strategy for the treatment of hypertension that would allow felodipine to be released at a certain time. By using the press coating approach, the system was created in the shape of two stacked tablets. Physical combinations of felodipine with innovative micro encapsulated solubilizers like Sepitrap 4000, Sepitrap 80 produced by direct compression process make up the active fast release core tablet. According to dissolution trials, core tablets containing these novel surfactants released the entire amount in 15 and 30 minutes, respectively. The decrease in crystallinity of felodipine, as determined by XRD data, was attributable to the enhanced dissolution and rapid release. Different grades of hydroxy propyl methyl cellulose (HPMC) E5, E15, and E50 were used to dry coat the optimised RRCT. Based on the in-vitro release profile, it was discovered that the improved formulation F6 had a 7.5-hour lag time, which was consistent with the chronotherapeutic goal of hypertension. The drug's crystallinity was reduced, with no interaction between the drug and the excipients, according to solid state characterization (FTIR, XRD tests).

Author(s) Details:

Rajeshri Dhurke,
Department of Pharmaceutics at St. Peter’s Institute of Pharmaceutical Sciences, Warangal, Telangana, India.

Domala Ramyasree,
Department of Pharmaceutics at St. Peter’s Institute of Pharmaceutical Sciences, Warangal, Telangana, India.

Please see the link here: https://stm.bookpi.org/CAPRD-V9/article/view/5971

A Brief Review on Chronobiology and Chronotherapy of Hypertension | Chapter 5 | Challenges in Disease and Health Research Vol. 8

 Hypertension affects more than 90% of all patients with cardiovascular disease (CVD) in the United States, and it is a major risk factor for end-organ injury, CVD, and mortality. Chronobiology, chronopharmacology, and chronotherapy in the management of hypertension have only been studied for a few decades. According to research conducted in the previous decade, our behaviour, such as what we eat, and the time of day, have an impact on blood pressure (BP) and cardiovascular disease (CVD). Furthermore, the potential of the night: day ratio of systolic BP to predict the risk of cardiovascular events is more accurate than office BP calculated only once. The evidence clearly reveals that nocturnal blood pressure is the type of blood pressure that is most consistently connected with cardiovascular risk prediction and allows for more frequent safety monitoring. The circadian rhythm is crucial for blood pressure regulation. As a result, the use of chronopharmacotherapy is required for a circadian condition like hypertension. Different drugs, on the other hand, have been investigated for their chronopharmacology and possible chronotherapy. This page discusses the chronobiology of hypertension, as well as the chronopharmacology and chronotherapy of the many medicines used to treat it. Researchers are likely to produce more creative chronopharmaceutical formulations for the control or treatment of hypertension now that they are aware of the risk factors connected with this illness problem.

Author (s) Details

K. Latha
G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad 500 028, India.

M. U. Uhumwangho
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria.

S. A. Sunil
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.

M. V. Srikanth
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.

K. V. Ramana Murthy
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.

View Book :- https://stm.bookpi.org/CDHR-V8/article/view/1423