Objective: To create a UV-VIS Spectrophotometric method for measuring adefovir, an anti-HIV medication, in bulk and pharmaceutical dose form that is simple, accurate, precise, and cost-effective.
The solvent employed was methanol, and the drug's maximum absorption peak was found to be 260 nm. Under ICH-recommended circumstances, defovir dipivoxil was subjected to stress degradation. The samples obtained this way were used in deterioration tests using the described approach.
With a regression coefficient of 0.999, a linear response was seen in the range of 5- 40g/ml. The approach was then tested for a number of parameters using ICH (International Conference on Harmonization) guidelines. Adefovir dissolves in acidic and alkaline environments, but stays relatively stable when subjected to dry heat, oxidation, and photolysis, according to stress degradation tests.
Conclusion: Without the use of excipients, this method can be used to determine adefovir in formulation quality control.
Author(s) Details:
Charushila H. Bhirud,
Pravara Institute of Medical Sciences Deemed University (PIMS), Loni,
Maharashtra, India.
Shivanand N. Hiremath,
Department of Pharmaceutical Sciences, Pravara Rural College of Pharmacy for
Women, Chincholi, Nasik, Pin-422102, Maharashtra, India.
Please see the link here: https://stm.bookpi.org/CAPRD-V9/article/view/5970
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