Determination of Pharmacological Screening for Anti-arthritic Potential of Moringa oleifera in Rats Challenged with Formalin | Chapter 5 | Technological Innovation in Pharmaceutical Research Vol. 9

Moringa oleifera Lam (Moringaceae), a plant of significant nutritional and therapeutic value endemic to the Indian subcontinent. Moringa's many portions have been used as a food supplement since the dawn of humanity. The most current evidence suggests that M. oleifera leaves could be used to treat a variety of inflammatory illnesses. The goal of this study was to look at arthritis and the preventive effects of Moringa oleifera (MO) leaf extracts in laboratory rats that had been exposed to formaldehyde. Methods: In albino Wistar rats, arthritis was produced by injecting 0.1 ml formaldehyde (2 percent v/v, sc) into the subplantar region of the right hind paw. The conventional medicine was diclofenac sodium (10 mg/kg, i.p.). For 10 days, ethanolic leaf extracts of MO at doses of 250 and 500 mg/kg, as well as aqueous leaf extract at 500 mg/kg body weight p.o., were given. Changes in paw edoema volume, paw thickness, arthritis score, and C-reactive protein (CRP) levels, as well as histology of knee joints in all groups, were documented at the end of the study period. Results: Treatment with diclofenac sodium, ethanolic, and aqueous extracts of MO resulted in a significant reduction in paw edoema volume, paw thickness, and arthritis score. When compared to control animals, there was a significant reduction in the marker of inflammation in the treated animals. In comparison to the toxicant, histological findings revealed that extract-treated tissues were restored to normalcy. Aqueous extract treatment at a dose of 500 mg/kg body weight was found to be more effective. Conclusion: At a dose of 500 mg/kg body weight, aqueous leaf extracts of MO had a greater anti-arthritic effect than ethanolic leaf extracts.

Author(s) Details

Professor, Dr. Nishat Fatima
Department of Pharmacology, Al Hawash Private University, Homs, Syria.

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