The goal of this investigation was to see if Vernonia amygdalina aqueous extract could protect abino wistar rats against acetaminophen-induced liver injury.
Methods: Twenty-five (25) albino rats weighing 120–20 g were allocated into five (5) groups, each with five (5) rats. Group A was used as a control group and did not receive any treatment. As a negative control, Group B received only a single dosage of acetaminophen (750 mg/kg, i.p.). Following an acetaminophen challenge, Group C got Vitamin C (200 mg/kg, oral) for 2 weeks, whereas Group D and E received aqueous bitter leaf extract; high dose (500 mg/kg, oral) and low dose (250 mg/kg, oral) separately for 2 weeks.
Results: A single dose of acetaminophen (750 mg/kg, i.p.) caused liver damage, with AST, ALT, and ALP values of 48.3310.14, 60.0013.23, and 229.6723.38U/L, respectively. When compared to acetaminophen alone, bitter leaf treatment reversed acetaminophen-induced liver damage, with AST, ALT, and ALP levels of 20.671.76U/L (P0.05), 16.673.52U/L (P0.01), and 131.677.27U/L (P0.01), respectively. The test groups likewise had mild or non-significant hepatic damage, indicating that Vernonia amygdalina provides hepatoprotection.
Conclusion: Vernonia amygdalina aqueous extract has hepatoprotective effects against acetaminophen-induced liver injury.
Author (S) Details
I. K. Uchendu
Department of Medical Laboratory Science, Division of Clinical Chemistry, University of Nigeria, Enugu Campus, Enugu State, Nigeria.
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