Thiazines are valuable units in medicinal and pharmaceutical chemistry, with a wide range of biological activity described. This prompted us to use thiourea, phenyl thiourea, and diphenyl thiourea to make chloro-substituted thiazines from 2'-hydroxy-3',5'-dichloro-4-4'-chlorophenyl chalcone. In this series, we made 4-(2'-hydroxy-3',5'-dichlorophenyl)-6- (4'-chlorophenyl)-4'-chlorophenyl)-4'-chlorophenyl)-4'-chlorophenyl)-4'-chlorophenyl)-4'-chlorophenyl)-4 4-(2'-hydroxy-3',5'-dichlorophenyl)-6-(4'-chlorophenyl)-2-imino-1,3-thiazine and 4-(2'-hydroxy-3',5'-dichlorophenyl)-4-(4'-chlorophenyl)-4-(4'-chlorophenyl)-4-(4'-chlorophen 4-(2'-hydroxy-3',5'-dichlorophenyl)-2-iminophenyl-1,3-thiazine and 4-(2'-hydroxy-3',5'-dichlorophenyl)-2-iminophenyl-1,3-thiazine from thiourea and phenyl thiourea, respectively. -6-(4'-chlorophenyl) Diphenyl thioure is converted to -2-iminophenyl-3-phenyl-1,3-thiazine. The antibacterial properties of newly synthesised chloro-substituted 1,3-thiazines were tested against Gram positive pathogens Staphylococcus aureus and Streptococcus sp., as well as Gram negative pathogens Pseudomonas sp. and Salmonella typhi. The UV, IR, and NMR spectrum investigations of all of these substances were used to describe them.
Author (S) Details
A. V. Gajbhiye
Department of Chemistry, MGV's A.S.C. College, Nampur-423 204, India.
View Book :- https://stm.bookpi.org/RTCAMS-V2/article/view/2911
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