Experiments have shown that its active ingredients [10] -gingerol has anti-diabetic properties in diabetic rats produced by streptozotocin (STZ) and a high-fat diet (HFD). Type 2 diabetes mellitus is quickly spreading among the world's population. With 62.4 million people living with type 2 diabetes, India is known as the "diabetes capital of the world." Insulin and oral hypoglycemic medicines such as sulfonylurea derivatives, thiazolidinediones, biguanides, and -glucosidase inhibitors are currently used to treat type 2 diabetes, but these medications have the majority of the negative effects. Wistar rats (150–200 g) were housed in groups of six (n=6) under a 12-hour light/dark cycle with controlled temperature and humidity (252°C, 55–65 percent relative humidity). In the pancreas of vehicle-treated animals, histological analysis revealed normal acini and cellular population in the islets of Langerhans. Our findings revealed that [10]-gingerol exerted anti-diabetic action in a dose-dependent manner. This research could help us better understand the role of [10]-gingerol in diabetic mellitus treatment.
Author (S) Details
Ashutosh Kumar Yadav
Department of Pharmacology, K.R. Mangalam University, Sohna Road, Gurgaon, India.
Reetu
Department of Pharmaceutics, K.R. Mangalam University, Sohna road, Gurgaon, India.
Arun Garg
Department of Pharmacology, K.R. Mangalam University, Sohna Road, Gurgaon, India.
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