The goal of this study was to see how different extracts of the whole plant of Borreria hispida (Linn) affected lipid levels in high-fat rats. Borreria hispida (Linn) dry powder was extracted using a Soxhlet extractor with various solvents (PE, EA, and methanol), and the crude various extract was used for hypolipidemic activities. All of the extracts were confirmed to be safe up to 2000mg/kg in the acute toxicity investigation, hence one hundredth of this dose was used as the assessment dose. Borreria hispida (Linn) extracts (Petroleum ether, Ethyl acetate, and Methanol) were given to rats fed a high-fat diet at a dose of 200mg/kg/day to see if they may help lower cholesterol levels. Six groups of six animals were formed from a total of 36 animals. Group I was normal, Group II was a high-fat diet, Group III was a high-fat diet plus pet.ether extract (200 mg/kg b.wt), Group IV was a high-fat diet plus ethyl acetate extract (200 mg/kg b.wt), Group V was a high-fat diet plus methanol extract (200 mg/kg b.wt), and Group VI was a high-fat diet plus atorvastatin (1.2) The HFD fed group had a noticeable rise in body weight (p0.001), which was reduced by the administration of Borreria hispida methanolic extract (200 mg/kg). Total cholesterol, triglycerides, phospholipids, LDL-C, and VLDL-C levels were all higher in rats on a high-fat diet (group II). When compared to HFD rats, rats treated with a methanolic extract of Borreria hispida (200mg/kg/day) showed a substantial (p0.001) decrease in body weight, plasma and tissue total cholesterol, triglycerides, phospholipids, plasma LDL-C and VLDL-C, as well as an increase in plasma HDL-C. (group II). The other two extract treatment groups did not provide similar results. Borreria hispida methanolic extract may protect against atherosclerosis and lower the atherogenic index compared to other extract treatment groups. This discovery gives some biochemical evidence for the use of a methanolic extract of the whole plant of Borreria hispida to prevent atherosclerosis and lower the atherogenic index, consequently bolstering the use of Borreria hispida in the management of atherosclerosis on a local level.
Author (S) Details
C. D. Shaji Selvin
St. John’s College of Pharmaceutical Science and Research, Kattappana South Post, Idukki Dist, Keralar- 685515, India.
Jambula Dinesh Babu
Department of Pharmacology, Scient Institute of Pharmacy, Ibrahimpatnam, Mandal, Ranga reddy Dist, Telangana-501 506, India.
A. Kottai Muthu
Department of Pharmacy, Annamalai University, Annamalai Nagar-608 002, Chidambaram, Tamilnadu, India.
View Book :- https://stm.bookpi.org/CACS-V3/article/view/2959
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